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Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.
Hakimi M, Selvanantham T, Swinton E, Padmore RF, Tong Y, Kabbach G, Venderova K, Girardin SE, Bulman DE, Scherzer CR, LaVoie MJ, Gris D, Park DS, Angel JB, Shen J, Philpott DJ, Schlossmacher MG. Hakimi M, et al. Among authors: girardin se. J Neural Transm (Vienna). 2011 May;118(5):795-808. doi: 10.1007/s00702-011-0653-2. Epub 2011 May 7. J Neural Transm (Vienna). 2011. PMID: 21552986 Free PMC article.
The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists.
Netea MG, Ferwerda G, de Jong DJ, Werts C, Boneca IG, Jéhanno M, Van Der Meer JW, Mengin-Lecreulx D, Sansonetti PJ, Philpott DJ, Dharancy S, Girardin SE. Netea MG, et al. Among authors: girardin se. J Biol Chem. 2005 Oct 28;280(43):35859-67. doi: 10.1074/jbc.M504924200. Epub 2005 Aug 22. J Biol Chem. 2005. PMID: 16115863 Free article.
188 results