Ryan AJ - Search Results

1

Vandetanib inhibits both VEGFR-2 and EGFR signalling at clinically relevant drug levels in preclinical models of human cancer.

Brave SR, Odedra R, James NH, Smith NR, Marshall GB, Acheson KL, Baker D, Howard Z, Jackson L, Ratcliffe K, Wainwright A, Lovick SC, Hickinson DM, Wilkinson RW, Barry ST, Speake G, Ryan AJ. Brave SR, et al. Among authors: ryan aj. Int J Oncol. 2011 Jul;39(1):271-8. doi: 10.3892/ijo.2011.1022. Epub 2011 Apr 29. Int J Oncol. 2011. PMID: 21537841

2

Effects of vandetanib on adenoma formation in a dextran sodium sulphate enhanced Apc(MIN/+) mouse model.

Alferez DG, Ryan AJ, Goodlad RA, Wright NA, Wilkinson RW. Alferez DG, et al. Among authors: ryan aj. Int J Oncol. 2010 Oct;37(4):767-72. doi: 10.3892/ijo_00000726. Int J Oncol. 2010. PMID: 20811697

3

Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia.

Alferez DG, Goodlad RA, Odedra R, Sini P, Crafter C, Ryan AJ, Wedge SR, Wright NA, Anderson E, Wilkinson RW. Alferez DG, et al. Among authors: ryan aj. Int J Oncol. 2012 Oct;41(4):1475-85. doi: 10.3892/ijo.2012.1580. Epub 2012 Jul 31. Int J Oncol. 2012. PMID: 22858681

4

Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers.

Smith NR, Baker D, James NH, Ratcliffe K, Jenkins M, Ashton SE, Sproat G, Swann R, Gray N, Ryan A, Jürgensmeier JM, Womack C. Smith NR, et al. Clin Cancer Res. 2010 Jul 15;16(14):3548-61. doi: 10.1158/1078-0432.CCR-09-2797. Epub 2010 Jul 6. Clin Cancer Res. 2010. PMID: 20606037

5

Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice.

Alferez D, Wilkinson RW, Watkins J, Poulsom R, Mandir N, Wedge SR, Pyrah IT, Smith NR, Jackson L, Ryan AJ, Goodlad RA. Alferez D, et al. Among authors: ryan aj. Mol Cancer Ther. 2008 Mar;7(3):590-8. doi: 10.1158/1535-7163.MCT-07-0433. Mol Cancer Ther. 2008. PMID: 18347145

6

Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer.

Goodlad RA, Ryan AJ, Wedge SR, Pyrah IT, Alferez D, Poulsom R, Smith NR, Mandir N, Watkins AJ, Wilkinson RW. Goodlad RA, et al. Among authors: ryan aj. Carcinogenesis. 2006 Oct;27(10):2133-9. doi: 10.1093/carcin/bgl113. Epub 2006 Jun 16. Carcinogenesis. 2006. PMID: 16782971

7

Effect of pretreatment with atenolol and nifedipine on ZD6126-induced cardiac toxicity in rats.

Gould S, Westwood FR, Curwen JO, Ashton SE, Roberts DW, Lovick SC, Ryan AJ. Gould S, et al. Among authors: ryan aj. J Natl Cancer Inst. 2007 Nov 21;99(22):1724-8. doi: 10.1093/jnci/djm202. Epub 2007 Nov 13. J Natl Cancer Inst. 2007. PMID: 18000220

8

Targeted therapy against VEGFR and EGFR with ZD6474 enhances the therapeutic efficacy of irradiation in an orthotopic model of human non-small-cell lung cancer.

Shibuya K, Komaki R, Shintani T, Itasaka S, Ryan A, Jürgensmeier JM, Milas L, Ang K, Herbst RS, O'Reilly MS. Shibuya K, et al. Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1534-43. doi: 10.1016/j.ijrobp.2007.07.2350. Epub 2007 Sep 24. Int J Radiat Oncol Biol Phys. 2007. PMID: 17889445 Free PMC article.

9

ZD6474--a novel inhibitor of VEGFR and EGFR tyrosine kinase activity.

Ryan AJ, Wedge SR. Ryan AJ, et al. Br J Cancer. 2005 Jun;92 Suppl 1(Suppl 1):S6-13. doi: 10.1038/sj.bjc.6602603. Br J Cancer. 2005. PMID: 15928657 Free PMC article. Review.

10

EGFR biomarkers predict benefit from vandetanib in combination with docetaxel in a randomized phase III study of second-line treatment of patients with advanced non-small cell lung cancer.

Heymach JV, Lockwood SJ, Herbst RS, Johnson BE, Ryan AJ. Heymach JV, et al. Among authors: ryan aj. Ann Oncol. 2014 Oct;25(10):1941-1948. doi: 10.1093/annonc/mdu269. Epub 2014 Jul 23. Ann Oncol. 2014. PMID: 25057173 Free PMC article. Clinical Trial.

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