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LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells.
Maia RC, Vasconcelos FC, de Sá Bacelar T, Salustiano EJ, da Silva LF, Pereira DL, Moellman-Coelho A, Netto CD, da Silva AJ, Rumjanek VM, Costa PR. Maia RC, et al. Among authors: netto cd. Invest New Drugs. 2011 Dec;29(6):1143-55. doi: 10.1007/s10637-010-9453-z. Epub 2010 May 25. Invest New Drugs. 2011. PMID: 20499132
Pterocarpanquinones, aza-pterocarpanquinone and derivatives: synthesis, antineoplasic activity on human malignant cell lines and antileishmanial activity on Leishmania amazonensis.
Buarque CD, Militão GC, Lima DJ, Costa-Lotufo LV, Pessoa C, de Moraes MO, Cunha-Junior EF, Torres-Santos EC, Netto CD, Costa PR. Buarque CD, et al. Among authors: netto cd. Bioorg Med Chem. 2011 Nov 15;19(22):6885-91. doi: 10.1016/j.bmc.2011.09.025. Epub 2011 Sep 21. Bioorg Med Chem. 2011. PMID: 22000949 Free article.
Further evidence that naphthoquinone inhibits Toxoplasma gondii growth in vitro.
da Silva LL, Portes Jde A, de Araújo MH, Silva JL, Rennó MN, Netto CD, da Silva AJ, Costa PR, De Souza W, Seabra SH, DaMatta RA. da Silva LL, et al. Among authors: netto cd. Parasitol Int. 2015 Dec;64(6):622-31. doi: 10.1016/j.parint.2015.08.010. Epub 2015 Sep 1. Parasitol Int. 2015. PMID: 26335616
Preclinical Studies Evaluating Subacute Toxicity and Therapeutic Efficacy of LQB-118 in Experimental Visceral Leishmaniasis.
Cunha-Júnior EF, Martins TM, Canto-Cavalheiro MM, Marques PR, Portari EA, Coelho MG, Netto CD, Costa PR, Sabino KC, Torres-Santos EC. Cunha-Júnior EF, et al. Among authors: netto cd. Antimicrob Agents Chemother. 2016 May 23;60(6):3794-801. doi: 10.1128/AAC.01787-15. Print 2016 Jun. Antimicrob Agents Chemother. 2016. PMID: 27067332 Free PMC article.
Anti-inflammatory properties of pterocarpanquinone LQB-118 in mice.
Riça IG, Netto CD, Rennó MN, Abreu PA, Costa PRR, da Silva AJM, Cavalcante MCM. Riça IG, et al. Among authors: netto cd. Bioorg Med Chem. 2016 Sep 15;24(18):4415-4423. doi: 10.1016/j.bmc.2016.07.046. Epub 2016 Jul 21. Bioorg Med Chem. 2016. PMID: 27492193 Free article.
Second-generation pterocarpanquinones: synthesis and antileishmanial activity.
Faiões VDS, da Frota LCRM, Cunha-Junior EF, Barcellos JCF, Da Silva T, Netto CD, Da-Silva SAG, da Silva AJM, Costa PRR, Torres-Santos EC. Faiões VDS, et al. Among authors: netto cd. J Venom Anim Toxins Incl Trop Dis. 2018 Nov 29;24:35. doi: 10.1186/s40409-018-0174-7. eCollection 2018. J Venom Anim Toxins Incl Trop Dis. 2018. PMID: 30519257 Free PMC article.
29 results