Tonge PJ - Search Results

1

Correction to "Machine learning-based method to improve docking scoring functions and its application to drug repurposing".

Kinnings SL, Liu N, Tonge PJ, Jackson RM, Xie L, Bourne PE. Kinnings SL, et al. Among authors: tonge pj. J Chem Inf Model. 2011 May 23;51(5):1195-7. doi: 10.1021/ci2001346. Epub 2011 Apr 28. J Chem Inf Model. 2011. PMID: 21526828 Free PMC article. No abstract available.

2

Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis.

Kinnings SL, Liu N, Buchmeier N, Tonge PJ, Xie L, Bourne PE. Kinnings SL, et al. Among authors: tonge pj. PLoS Comput Biol. 2009 Jul;5(7):e1000423. doi: 10.1371/journal.pcbi.1000423. Epub 2009 Jul 3. PLoS Comput Biol. 2009. PMID: 19578428 Free PMC article.

3

A slow, tight binding inhibitor of InhA, the enoyl-acyl carrier protein reductase from Mycobacterium tuberculosis.

Luckner SR, Liu N, am Ende CW, Tonge PJ, Kisker C. Luckner SR, et al. Among authors: tonge pj. J Biol Chem. 2010 May 7;285(19):14330-7. doi: 10.1074/jbc.M109.090373. Epub 2010 Mar 3. J Biol Chem. 2010. PMID: 20200152 Free PMC article.

4

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Li X, Liu N, Zhang H, Knudson SE, Slayden RA, Tonge PJ. Li X, et al. Among authors: tonge pj. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6306-9. doi: 10.1016/j.bmcl.2010.08.076. Epub 2010 Aug 21. Bioorg Med Chem Lett. 2010. PMID: 20850304 Free PMC article.

5

A machine learning-based method to improve docking scoring functions and its application to drug repurposing.

Kinnings SL, Liu N, Tonge PJ, Jackson RM, Xie L, Bourne PE. Kinnings SL, et al. Among authors: tonge pj. J Chem Inf Model. 2011 Feb 28;51(2):408-19. doi: 10.1021/ci100369f. Epub 2011 Feb 3. J Chem Inf Model. 2011. PMID: 21291174 Free PMC article.

6

Mechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomallei.

Liu N, Cummings JE, England K, Slayden RA, Tonge PJ. Liu N, et al. Among authors: tonge pj. J Antimicrob Chemother. 2011 Mar;66(3):564-73. doi: 10.1093/jac/dkq509. Epub 2011 Jan 22. J Antimicrob Chemother. 2011. PMID: 21393229 Free PMC article.

7

Mechanism of the intramolecular Claisen condensation reaction catalyzed by MenB, a crotonase superfamily member.

Li HJ, Li X, Liu N, Zhang H, Truglio JJ, Mishra S, Kisker C, Garcia-Diaz M, Tonge PJ. Li HJ, et al. Among authors: tonge pj. Biochemistry. 2011 Nov 8;50(44):9532-44. doi: 10.1021/bi200877x. Epub 2011 Oct 11. Biochemistry. 2011. PMID: 21830810 Free PMC article.

8

Structure of the Yersinia pestis FabV enoyl-ACP reductase and its interaction with two 2-pyridone inhibitors.

Hirschbeck MW, Kuper J, Lu H, Liu N, Neckles C, Shah S, Wagner S, Sotriffer CA, Tonge PJ, Kisker C. Hirschbeck MW, et al. Among authors: tonge pj. Structure. 2012 Jan 11;20(1):89-100. doi: 10.1016/j.str.2011.07.019. Structure. 2012. PMID: 22244758 Free PMC article.

9

CoA Adducts of 4-Oxo-4-Phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis Menaquinone Biosynthesis Pathway.

Li X, Liu N, Zhang H, Knudson SE, Li HJ, Lai CT, Simmerling C, Slayden RA, Tonge PJ. Li X, et al. Among authors: tonge pj. ACS Med Chem Lett. 2011 Nov 10;2(11):818-823. doi: 10.1021/ml200141e. ACS Med Chem Lett. 2011. PMID: 22267981 Free PMC article.

10

A structural and energetic model for the slow-onset inhibition of the Mycobacterium tuberculosis enoyl-ACP reductase InhA.

Li HJ, Lai CT, Pan P, Yu W, Liu N, Bommineni GR, Garcia-Diaz M, Simmerling C, Tonge PJ. Li HJ, et al. Among authors: tonge pj. ACS Chem Biol. 2014 Apr 18;9(4):986-93. doi: 10.1021/cb400896g. Epub 2014 Mar 10. ACS Chem Biol. 2014. PMID: 24527857 Free PMC article.

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