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ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors.
Bollyky PL, Wu RP, Falk BA, Lord JD, Long SA, Preisinger A, Teng B, Holt GE, Standifer NE, Braun KR, Xie CF, Samuels PL, Vernon RB, Gebe JA, Wight TN, Nepom GT. Bollyky PL, et al. Among authors: lord jd. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7938-43. doi: 10.1073/pnas.1017360108. Epub 2011 Apr 25. Proc Natl Acad Sci U S A. 2011. PMID: 21518860 Free PMC article.
FOXP3+ regulatory T cells use heparanase to access IL-2 bound to ECM in inflamed tissues.
Martinez HA, Koliesnik I, Kaber G, Reid JK, Nagy N, Barlow G, Falk BA, Medina CO, Hargil A, Vlodavsky I, Li JP, Pérez-Cruz M, Tang SW, Meyer EH, Wrenshall LE, Lord JD, Garcia KC, Palmer TD, Steinman L, Nepom GT, Wight TN, Bollyky PL, Kuipers HF. Martinez HA, et al. Among authors: lord jd. bioRxiv [Preprint]. 2023 Feb 27:2023.02.26.529772. doi: 10.1101/2023.02.26.529772. bioRxiv. 2023. Update in: Nat Commun. 2024 Feb 20;15(1):1564. doi: 10.1038/s41467-024-45012-9 PMID: 36909599 Free PMC article. Updated. Preprint.
Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.
Martinez HA, Koliesnik I, Kaber G, Reid JK, Nagy N, Barlow G, Falk BA, Medina CO, Hargil A, Zihsler S, Vlodavsky I, Li JP, Pérez-Cruz M, Tang SW, Meyer EH, Wrenshall LE, Lord JD, Garcia KC, Palmer TD, Steinman L, Nepom GT, Wight TN, Bollyky PL, Kuipers HF. Martinez HA, et al. Among authors: lord jd. Nat Commun. 2024 Feb 20;15(1):1564. doi: 10.1038/s41467-024-45012-9. Nat Commun. 2024. PMID: 38378682 Free PMC article.
45 results