Lu XY - Search Results

1

Recent developments in the third generation inhibitors of Bcr-Abl for overriding T315I mutation.

Lu XY, Cai Q, Ding K. Lu XY, et al. Curr Med Chem. 2011;18(14):2146-57. doi: 10.2174/092986711795656135. Curr Med Chem. 2011. PMID: 21517764 Review.

2

Recent progress of SRC family kinase inhibitors as anticancer agents.

Cao X, You QD, Li ZY, Wang XJ, Lu XY, Liu XR, Xu D, Liu B. Cao X, et al. Among authors: lu xy. Mini Rev Med Chem. 2008 Sep;8(10):1053-63. doi: 10.2174/138955708785740634. Mini Rev Med Chem. 2008. PMID: 18782057 Review.

3

Hybrid compounds as new Bcr/Abl inhibitors.

Wang D, Zhang Z, Lu X, Feng Y, Luo K, Gan J, Yingxue L, Wan J, Li X, Zhang F, Tu Z, Cai Q, Ren X, Ding K. Wang D, et al. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1965-8. doi: 10.1016/j.bmcl.2011.02.029. Epub 2011 Feb 13. Bioorg Med Chem Lett. 2011. PMID: 21376587

4

New thiazole carboxamides as potent inhibitors of Akt kinases.

Chang S, Zhang Z, Zhuang X, Luo J, Cao X, Li H, Tu Z, Lu X, Ren X, Ding K. Chang S, et al. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1208-12. doi: 10.1016/j.bmcl.2011.11.080. Epub 2011 Nov 30. Bioorg Med Chem Lett. 2012. PMID: 22172705

5

Design, synthesis, and in vitro biological evaluation of 1H-1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents targeting virus nucleoprotein.

Cheng H, Wan J, Lin MI, Liu Y, Lu X, Liu J, Xu Y, Chen J, Tu Z, Cheng YS, Ding K. Cheng H, et al. J Med Chem. 2012 Mar 8;55(5):2144-53. doi: 10.1021/jm2013503. Epub 2012 Feb 27. J Med Chem. 2012. PMID: 22332894

6

Design, synthesis, and biological evaluation of novel conformationally constrained inhibitors targeting epidermal growth factor receptor threonine⁷⁹⁰ → methionine⁷⁹⁰ mutant.

Chang S, Zhang L, Xu S, Luo J, Lu X, Zhang Z, Xu T, Liu Y, Tu Z, Xu Y, Ren X, Geng M, Ding J, Pei D, Ding K. Chang S, et al. J Med Chem. 2012 Mar 22;55(6):2711-23. doi: 10.1021/jm201591k. Epub 2012 Mar 1. J Med Chem. 2012. PMID: 22339342

7

Recent advance in the design of small molecular modulators of estrogen-related receptors.

Lu X, Peng L, Lv M, ding K. Lu X, et al. Curr Pharm Des. 2012;18(23):3421-31. doi: 10.2174/138161212801227113. Curr Pharm Des. 2012. PMID: 22632982 Review.

8

Pharmacophore and molecular docking guided 3D-QSAR study of bacterial enoyl-ACP reductase (FabI) Inhibitors.

Lu X, Lv M, Huang K, Ding K, You Q. Lu X, et al. Int J Mol Sci. 2012;13(6):6620-6638. doi: 10.3390/ijms13066620. Epub 2012 Mar 20. Int J Mol Sci. 2012. PMID: 22837653 Free PMC article.

9

Design, synthesis, and biological evaluation of 3-(1H-1,2,3-triazol-1-yl)benzamide derivatives as Potent Pan Bcr-Abl inhibitors including the threonine(315)→isoleucine(315) mutant.

Li Y, Shen M, Zhang Z, Luo J, Pan X, Lu X, Long H, Wen D, Zhang F, Leng F, Li Y, Tu Z, Ren X, Ding K. Li Y, et al. J Med Chem. 2012 Nov 26;55(22):10033-46. doi: 10.1021/jm301188x. Epub 2012 Nov 1. J Med Chem. 2012. PMID: 23088644

10

Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib.

Ren X, Pan X, Zhang Z, Wang D, Lu X, Li Y, Wen D, Long H, Luo J, Feng Y, Zhuang X, Zhang F, Liu J, Leng F, Lang X, Bai Y, She M, Tu Z, Pan J, Ding K. Ren X, et al. J Med Chem. 2013 Feb 14;56(3):879-94. doi: 10.1021/jm301581y. Epub 2013 Jan 28. J Med Chem. 2013. PMID: 23301703

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