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Page 1
Preclinical characteristics of the hepatitis C virus NS3/4A protease inhibitor ITMN-191 (R7227).
Seiwert SD, Andrews SW, Jiang Y, Serebryany V, Tan H, Kossen K, Rajagopalan PT, Misialek S, Stevens SK, Stoycheva A, Hong J, Lim SR, Qin X, Rieger R, Condroski KR, Zhang H, Do MG, Lemieux C, Hingorani GP, Hartley DP, Josey JA, Pan L, Beigelman L, Blatt LM. Seiwert SD, et al. Among authors: kossen k. Antimicrob Agents Chemother. 2008 Dec;52(12):4432-41. doi: 10.1128/AAC.00699-08. Epub 2008 Sep 29. Antimicrob Agents Chemother. 2008. PMID: 18824605 Free PMC article.
Virologic escape during danoprevir (ITMN-191/RG7227) monotherapy is hepatitis C virus subtype dependent and associated with R155K substitution.
Lim SR, Qin X, Susser S, Nicholas JB, Lange C, Herrmann E, Hong J, Arfsten A, Hooi L, Bradford W, Nájera I, Smith P, Zeuzem S, Kossen K, Sarrazin C, Seiwert SD. Lim SR, et al. Among authors: kossen k. Antimicrob Agents Chemother. 2012 Jan;56(1):271-9. doi: 10.1128/AAC.05636-11. Epub 2011 Nov 7. Antimicrob Agents Chemother. 2012. PMID: 22064535 Free PMC article. Clinical Trial.
Preclinical Characterization and Human Microdose Pharmacokinetics of ITMN-8187, a Nonmacrocyclic Inhibitor of the Hepatitis C Virus NS3 Protease.
Rajagopalan R, Pan L, Schaefer C, Nicholas J, Lim S, Misialek S, Stevens S, Hooi L, Aleskovski N, Ruhrmund D, Kossen K, Huang L, Yap S, Beigelman L, Serebryany V, Liu J, Sastry S, Seiwert S, Buckman B. Rajagopalan R, et al. Among authors: kossen k. Antimicrob Agents Chemother. 2016 Dec 27;61(1):e01569-16. doi: 10.1128/AAC.01569-16. Print 2017 Jan. Antimicrob Agents Chemother. 2016. PMID: 27795376 Free PMC article.
Antifibrotic activities of pirfenidone in animal models.
Schaefer CJ, Ruhrmund DW, Pan L, Seiwert SD, Kossen K. Schaefer CJ, et al. Among authors: kossen k. Eur Respir Rev. 2011 Jun;20(120):85-97. doi: 10.1183/09059180.00001111. Eur Respir Rev. 2011. PMID: 21632796 Free PMC article. Review.
HCV NS5B polymerase inhibitors 3: Synthesis and in vitro activity of 3-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy-2H-quinolizin-2-one derivatives.
Wang G, Zhang L, Wu X, Das D, Ruhrmund D, Hooi L, Misialek S, Ravi Rajagopalan PT, Buckman BO, Kossen K, Seiwert SD, Beigelman L. Wang G, et al. Among authors: kossen k. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4484-7. doi: 10.1016/j.bmcl.2009.05.021. Epub 2009 May 9. Bioorg Med Chem Lett. 2009. PMID: 19497737
HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives.
Wang G, Lei H, Wang X, Das D, Hong J, Mackinnon CH, Coulter TS, Montalbetti CA, Mears R, Gai X, Bailey SE, Ruhrmund D, Hooi L, Misialek S, Rajagopalan PT, Cheng RK, Barker JJ, Felicetti B, Schönfeld DL, Stoycheva A, Buckman BO, Kossen K, Seiwert SD, Beigelman L. Wang G, et al. Among authors: kossen k. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4480-3. doi: 10.1016/j.bmcl.2009.05.022. Epub 2009 May 9. Bioorg Med Chem Lett. 2009. PMID: 19500983
HCV NS5B polymerase inhibitors 1: Synthesis and in vitro activity of 2-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives.
Wang G, He Y, Sun J, Das D, Hu M, Huang J, Ruhrmund D, Hooi L, Misialek S, Ravi Rajagopalan PT, Stoycheva A, Buckman BO, Kossen K, Seiwert SD, Beigelman L. Wang G, et al. Among authors: kossen k. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4476-9. doi: 10.1016/j.bmcl.2009.05.063. Epub 2009 May 23. Bioorg Med Chem Lett. 2009. PMID: 19502055
25 results