Sasaki AT - Search Results

1

A fluorescent reporter of AMPK activity and cellular energy stress.

Tsou P, Zheng B, Hsu CH, Sasaki AT, Cantley LC. Tsou P, et al. Among authors: sasaki at. Cell Metab. 2011 Apr 6;13(4):476-486. doi: 10.1016/j.cmet.2011.03.006. Cell Metab. 2011. PMID: 21459332 Free PMC article.

2

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.

Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Egia A, Sasaki AT, Thomas G, Kozma SC, Papa A, Nardella C, Cantley LC, Baselga J, Pandolfi PP. Carracedo A, et al. Among authors: sasaki at. J Clin Invest. 2008 Sep;118(9):3065-74. doi: 10.1172/JCI34739. J Clin Invest. 2008. PMID: 18725988 Free PMC article.

3

Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.

Sasaki AT, Carracedo A, Locasale JW, Anastasiou D, Takeuchi K, Kahoud ER, Haviv S, Asara JM, Pandolfi PP, Cantley LC. Sasaki AT, et al. Sci Signal. 2011 Mar 8;4(163):ra13. doi: 10.1126/scisignal.2001518. Sci Signal. 2011. PMID: 21386094 Free PMC article.

4

Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways.

Hanai J, Doro N, Sasaki AT, Kobayashi S, Cantley LC, Seth P, Sukhatme VP. Hanai J, et al. Among authors: sasaki at. J Cell Physiol. 2012 Apr;227(4):1709-20. doi: 10.1002/jcp.22895. J Cell Physiol. 2012. PMID: 21688263 Free PMC article.

5

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.

Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Ligon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC, Vander Heiden MG. Locasale JW, et al. Among authors: sasaki m, sasaki at. Nat Genet. 2011 Jul 31;43(9):869-74. doi: 10.1038/ng.890. Nat Genet. 2011. PMID: 21804546 Free PMC article.

6

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.

Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang JK, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, Thomas CJ, Vander Heiden MG, Cantley LC. Anastasiou D, et al. Among authors: sasaki at. Science. 2011 Dec 2;334(6060):1278-83. doi: 10.1126/science.1211485. Epub 2011 Nov 3. Science. 2011. PMID: 22052977 Free PMC article.

7

Characterization of KRAS rearrangements in metastatic prostate cancer.

Wang XS, Shankar S, Dhanasekaran SM, Ateeq B, Sasaki AT, Jing X, Robinson D, Cao Q, Prensner JR, Yocum AK, Wang R, Fries DF, Han B, Asangani IA, Cao X, Li Y, Omenn GS, Pflueger D, Gopalan A, Reuter VE, Kahoud ER, Cantley LC, Rubin MA, Palanisamy N, Varambally S, Chinnaiyan AM. Wang XS, et al. Among authors: sasaki at. Cancer Discov. 2011 Jun;1(1):35-43. doi: 10.1158/2159-8274.CD-10-0022. Epub 2011 Jun 1. Cancer Discov. 2011. PMID: 22140652 Free PMC article.

8

Systemic elevation of PTEN induces a tumor-suppressive metabolic state.

Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP. Garcia-Cao I, et al. Among authors: sasaki at. Cell. 2012 Mar 30;149(1):49-62. doi: 10.1016/j.cell.2012.02.030. Epub 2012 Mar 6. Cell. 2012. PMID: 22401813 Free PMC article.

9

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.

Baker R, Lewis SM, Sasaki AT, Wilkerson EM, Locasale JW, Cantley LC, Kuhlman B, Dohlman HG, Campbell SL. Baker R, et al. Among authors: sasaki at. Nat Struct Mol Biol. 2013 Jan;20(1):46-52. doi: 10.1038/nsmb.2430. Epub 2012 Nov 25. Nat Struct Mol Biol. 2013. PMID: 23178454 Free PMC article.

10

A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation.

Davis MI, Sasaki AT, Shen M, Emerling BM, Thorne N, Michael S, Pragani R, Boxer M, Sumita K, Takeuchi K, Auld DS, Li Z, Cantley LC, Simeonov A. Davis MI, et al. Among authors: sasaki at. PLoS One. 2013;8(1):e54127. doi: 10.1371/journal.pone.0054127. Epub 2013 Jan 10. PLoS One. 2013. PMID: 23326584 Free PMC article.

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