Huston E - Search Results

1

Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).

Day JP, Lindsay B, Riddell T, Jiang Z, Allcock RW, Abraham A, Sookup S, Christian F, Bogum J, Martin EK, Rae RL, Anthony D, Rosair GM, Houslay DM, Huston E, Baillie GS, Klussmann E, Houslay MD, Adams DR. Day JP, et al. Among authors: huston e. J Med Chem. 2011 May 12;54(9):3331-47. doi: 10.1021/jm200070e. Epub 2011 Apr 13. J Med Chem. 2011. PMID: 21456625

2

Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene.

Johnston LA, Erdogan S, Cheung YF, Sullivan M, Barber R, Lynch MJ, Baillie GS, Van Heeke G, Adams DR, Huston E, Houslay MD. Johnston LA, et al. Among authors: huston e. Biochem J. 2004 Jun 1;380(Pt 2):371-84. doi: 10.1042/BJ20031662. Biochem J. 2004. PMID: 15025561 Free PMC article.

3

cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling.

Huston E, Houslay TM, Baillie GS, Houslay MD. Huston E, et al. Biochem Soc Trans. 2006 Aug;34(Pt 4):504-9. doi: 10.1042/BST0340504. Biochem Soc Trans. 2006. PMID: 16856845

4

In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting.

Beard MB, Huston E, Campbell L, Gall I, McPhee I, Yarwood S, Scotland G, Houslay MD. Beard MB, et al. Among authors: huston e. Cell Signal. 2002 May;14(5):453-65. doi: 10.1016/s0898-6568(01)00264-9. Cell Signal. 2002. PMID: 11882390

5

TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid.

Baillie GS, Huston E, Scotland G, Hodgkin M, Gall I, Peden AH, MacKenzie C, Houslay ES, Currie R, Pettitt TR, Walmsley AR, Wakelam MJ, Warwicker J, Houslay MD. Baillie GS, et al. Among authors: huston e. J Biol Chem. 2002 Aug 2;277(31):28298-309. doi: 10.1074/jbc.M108353200. Epub 2002 May 6. J Biol Chem. 2002. PMID: 11994273 Free article.

6

Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process.

Terry R, Cheung YF, Praestegaard M, Baillie GS, Huston E, Gall I, Adams DR, Houslay MD. Terry R, et al. Among authors: huston e. Cell Signal. 2003 Oct;15(10):955-71. doi: 10.1016/s0898-6568(03)00092-5. Cell Signal. 2003. PMID: 12873709

7

Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene.

Wallace DA, Johnston LA, Huston E, MacMaster D, Houslay TM, Cheung YF, Campbell L, Millen JE, Smith RA, Gall I, Knowles RG, Sullivan M, Houslay MD. Wallace DA, et al. Among authors: huston e. Mol Pharmacol. 2005 Jun;67(6):1920-34. doi: 10.1124/mol.104.009423. Epub 2005 Feb 28. Mol Pharmacol. 2005. PMID: 15738310

8

In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region.

McCahill A, McSorley T, Huston E, Hill EV, Lynch MJ, Gall I, Keryer G, Lygren B, Tasken K, van Heeke G, Houslay MD. McCahill A, et al. Among authors: huston e. Cell Signal. 2005 Sep;17(9):1158-73. doi: 10.1016/j.cellsig.2005.04.003. Cell Signal. 2005. PMID: 15905070

9

Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.

Li X, Huston E, Lynch MJ, Houslay MD, Baillie GS. Li X, et al. Among authors: huston e. Biochem J. 2006 Mar 1;394(Pt 2):427-35. doi: 10.1042/BJ20051560. Biochem J. 2006. PMID: 16356165 Free PMC article.

10

Helix-1 of the cAMP-specific phosphodiesterase PDE4A1 regulates its phospholipase-D-dependent redistribution in response to release of Ca2+.

Huston E, Gall I, Houslay TM, Houslay MD. Huston E, et al. J Cell Sci. 2006 Sep 15;119(Pt 18):3799-810. doi: 10.1242/jcs.03106. Epub 2006 Aug 29. J Cell Sci. 2006. PMID: 16940352

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