Bigge CF - Search Results

1

New and versatile approaches to the synthesis of CPP-related competitive NMDA antagonists. Preliminary structure-activity relationships and pharmacological evaluation.

Hays SJ, Bigge CF, Novak PM, Drummond JT, Bobovski TP, Rice MJ, Johnson G, Brahce LJ, Coughenour LL. Hays SJ, et al. Among authors: bigge cf. J Med Chem. 1990 Oct;33(10):2916-24. doi: 10.1021/jm00172a037. J Med Chem. 1990. PMID: 2145436

2

Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists.

Ortwine DF, Malone TC, Bigge CF, Drummond JT, Humblet C, Johnson G, Pinter GW. Ortwine DF, et al. Among authors: bigge cf. J Med Chem. 1992 Apr 17;35(8):1345-70. doi: 10.1021/jm00086a004. J Med Chem. 1992. PMID: 1533422

3

Exploration of N-phosphonoalkyl-, N-phosphonoalkenyl-, and N-(phosphonoalkyl)phenyl-spaced alpha-amino acids as competitive N-methyl-D-aspartic acid antagonists.

Bigge CF, Johnson G, Ortwine DF, Drummond JT, Retz DM, Brahce LJ, Coughenour LL, Marcoux FW, Probert AW Jr. Bigge CF, et al. J Med Chem. 1992 Apr 17;35(8):1371-84. doi: 10.1021/jm00086a005. J Med Chem. 1992. PMID: 1533423

4

Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists.

Bigge CF, Drummond JT, Johnson G, Malone T, Probert AW Jr, Marcoux FW, Coughenour LL, Brahce LJ. Bigge CF, et al. J Med Chem. 1989 Jul;32(7):1580-90. doi: 10.1021/jm00127a030. J Med Chem. 1989. PMID: 2544728

5

Synthesis and pharmacological evaluation of 4a-phenanthrenamine derivatives acting at the phencyclidine binding site of the N-methyl-D-aspartate receptor complex.

Bigge CF, Malone TC, Hays SJ, Johnson G, Novak PM, Lescosky LJ, Retz DM, Ortwine DF, Probert AW Jr, Coughenour LL, et al. Bigge CF, et al. J Med Chem. 1993 Jul 9;36(14):1977-95. doi: 10.1021/jm00066a007. J Med Chem. 1993. PMID: 8336337

6

Synthesis and pharmacological evaluation of hexahydrofluorenamines as noncompetitive antagonists at the N-methyl-D-aspartate receptor.

Hays SJ, Novak PM, Ortwine DF, Bigge CF, Colbry NL, Johnson G, Lescosky LJ, Malone TC, Michael A, Reily MD, et al. Hays SJ, et al. Among authors: bigge cf. J Med Chem. 1993 Mar 19;36(6):654-70. doi: 10.1021/jm00058a002. J Med Chem. 1993. PMID: 8459395

7

4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist.

Zhou ZL, Cai SX, Whittemore ER, Konkoy CS, Espitia SA, Tran M, Rock DM, Coughenour LL, Hawkinson JE, Boxer PA, Bigge CF, Wise LD, Weber E, Woodward RM, Keana JF. Zhou ZL, et al. Among authors: bigge cf. J Med Chem. 1999 Jul 29;42(15):2993-3000. doi: 10.1021/jm990246i. J Med Chem. 1999. PMID: 10425109

8

Potent, orally active, competitive N-methyl-D-aspartate (NMDA) receptor antagonists are substrates for a neutral amino acid uptake system in Chinese hamster ovary cells.

Li JH, Bigge CF, Williamson RM, Borosky SA, Vartanian MG, Ortwine DF. Li JH, et al. Among authors: bigge cf. J Med Chem. 1995 May 26;38(11):1955-65. doi: 10.1021/jm00011a015. J Med Chem. 1995. PMID: 7783127

9

Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity.

Bigge CF, Malone TC, Boxer PA, Nelson CB, Ortwine DF, Schelkun RM, Retz DM, Lescosky LJ, Borosky SA, Vartanian MG, et al. Bigge CF, et al. J Med Chem. 1995 Sep 15;38(19):3720-40. doi: 10.1021/jm00019a003. J Med Chem. 1995. PMID: 7562904

10

Design, synthesis, and biological activity of novel polycyclic aza-amide FKBP12 ligands.

Hudack RA Jr, Barta NS, Guo C, Deal J, Dong L, Fay LK, Caprathe B, Chatterjee A, Vanderpool D, Bigge C, Showalter R, Bender S, Augelli-Szafran CE, Lunney E, Hou X. Hudack RA Jr, et al. J Med Chem. 2006 Feb 9;49(3):1202-6. doi: 10.1021/jm049161u. J Med Chem. 2006. PMID: 16451085

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

35 results

Search Page

Filters