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Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.
Castellano S, Spannhoff A, Milite C, Dal Piaz F, Cheng D, Tosco A, Viviano M, Yamani A, Cianciulli A, Sala M, Cura V, Cavarelli J, Novellino E, Mai A, Bedford MT, Sbardella G. Castellano S, et al. Among authors: bedford mt. J Med Chem. 2012 Nov 26;55(22):9875-90. doi: 10.1021/jm301097p. Epub 2012 Nov 2. J Med Chem. 2012. PMID: 23095008 Free PMC article.
Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation.
Metzger E, Willmann D, McMillan J, Forne I, Metzger P, Gerhardt S, Petroll K, von Maessenhausen A, Urban S, Schott AK, Espejo A, Eberlin A, Wohlwend D, Schüle KM, Schleicher M, Perner S, Bedford MT, Jung M, Dengjel J, Flaig R, Imhof A, Einsle O, Schüle R. Metzger E, et al. Among authors: bedford mt. Nat Struct Mol Biol. 2016 Feb;23(2):132-9. doi: 10.1038/nsmb.3153. Epub 2016 Jan 11. Nat Struct Mol Biol. 2016. PMID: 26751641
Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
Iannelli G, Milite C, Marechal N, Cura V, Bonnefond L, Troffer-Charlier N, Feoli A, Rescigno D, Wang Y, Cipriano A, Viviano M, Bedford MT, Cavarelli J, Castellano S, Sbardella G. Iannelli G, et al. Among authors: bedford mt. J Med Chem. 2022 Sep 8;65(17):11574-11606. doi: 10.1021/acs.jmedchem.2c00252. Epub 2022 Apr 28. J Med Chem. 2022. PMID: 35482954 Free PMC article.
227 results