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Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide.
Zehnder L, Bennett M, Meng J, Huang B, Ninkovic S, Wang F, Braganza J, Tatlock J, Jewell T, Zhou JZ, Burke B, Wang J, Maegley K, Mehta PP, Yin MJ, Gajiwala KS, Hickey MJ, Yamazaki S, Smith E, Kang P, Sistla A, Dovalsantos E, Gehring MR, Kania R, Wythes M, Kung PP. Zehnder L, et al. Among authors: bennett m. J Med Chem. 2011 May 12;54(9):3368-85. doi: 10.1021/jm200128m. Epub 2011 Apr 20. J Med Chem. 2011. PMID: 21438541
Synthesis and biological activity of CCK heptapeptide analogues. Effects of conformational constraints and standard modifications on receptor subtype selectivity, functional activity in vitro, and appetite suppression in vivo.
Holladay MW, Bennett MJ, Tufano MD, Lin CW, Asin KE, Witte DG, Miller TR, Bianchi BR, Nikkel AL, Bednarz L, et al. Holladay MW, et al. Among authors: bennett mj. J Med Chem. 1992 Aug 7;35(16):2919-28. doi: 10.1021/jm00094a001. J Med Chem. 1992. PMID: 1501220
Cytosine-Based TET Enzyme Inhibitors.
Chua GNL, Wassarman KL, Sun H, Alp JA, Jarczyk EI, Kuzio NJ, Bennett MJ, Malachowsky BG, Kruse M, Kennedy AJ. Chua GNL, et al. Among authors: bennett mj. ACS Med Chem Lett. 2019 Jan 31;10(2):180-185. doi: 10.1021/acsmedchemlett.8b00474. eCollection 2019 Feb 14. ACS Med Chem Lett. 2019. PMID: 30783500 Free PMC article.
Functional screening identifies miRNAs with a novel function inhibiting Vascular Smooth Muscle Cell proliferation.
Rodor J, Klimi E, Brown SD, Krilis G, Braga L, Ring NAR, Ballantyne MD, Kesidou D, Dinh Cat AN, Miscianinov V, Vacante F, Miteva K, Bennett M, Beqqali A, Giacca M, Zacchigna S, Baker AH. Rodor J, et al. Among authors: bennett m. Mol Ther. 2024 Dec 30:S1525-0016(24)00837-2. doi: 10.1016/j.ymthe.2024.12.037. Online ahead of print. Mol Ther. 2024. PMID: 39736815
5,225 results