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15 results

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Page 1
Phenoxyacetic acids as PPARδ partial agonists: synthesis, optimization, and in vivo efficacy.
Evans KA, Shearer BG, Wisnoski DD, Shi D, Sparks SM, Sternbach DD, Winegar DA, Billin AN, Britt C, Way JM, Epperly AH, Leesnitzer LM, Merrihew RV, Xu RX, Lambert MH, Jin J. Evans KA, et al. Among authors: merrihew rv. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2345-50. doi: 10.1016/j.bmcl.2011.02.077. Epub 2011 Mar 15. Bioorg Med Chem Lett. 2011. PMID: 21414782
Discovery of a novel class of PPARdelta partial agonists.
Shearer BG, Patel HS, Billin AN, Way JM, Winegar DA, Lambert MH, Xu RX, Leesnitzer LM, Merrihew RV, Huet S, Willson TM. Shearer BG, et al. Among authors: merrihew rv. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5018-22. doi: 10.1016/j.bmcl.2008.08.011. Epub 2008 Aug 9. Bioorg Med Chem Lett. 2008. PMID: 18722772
Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.
Shearer BG, Wiethe RW, Ashe A, Billin AN, Way JM, Stanley TB, Wagner CD, Xu RX, Leesnitzer LM, Merrihew RV, Shearer TW, Jeune MR, Ulrich JC, Willson TM. Shearer BG, et al. Among authors: merrihew rv. J Med Chem. 2010 Feb 25;53(4):1857-61. doi: 10.1021/jm900464j. J Med Chem. 2010. PMID: 20128594
Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARγ partial agonist.
Sime M, Allan AC, Chapman P, Fieldhouse C, Giblin GM, Healy MP, Lambert MH, Leesnitzer LM, Lewis A, Merrihew RV, Rutter RA, Sasse R, Shearer BG, Willson TM, Xu RX, Virley DJ. Sime M, et al. Among authors: merrihew rv. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5568-72. doi: 10.1016/j.bmcl.2011.06.088. Epub 2011 Jun 29. Bioorg Med Chem Lett. 2011. PMID: 21798739
Optimizing Ligand Efficiency of Selective Androgen Receptor Modulators (SARMs).
Handlon AL, Schaller LT, Leesnitzer LM, Merrihew RV, Poole C, Ulrich JC, Wilson JW, Cadilla R, Turnbull P. Handlon AL, et al. Among authors: merrihew rv. ACS Med Chem Lett. 2015 Nov 19;7(1):83-8. doi: 10.1021/acsmedchemlett.5b00377. eCollection 2016 Jan 14. ACS Med Chem Lett. 2015. PMID: 26819671 Free PMC article.
Baculoviruses and mammalian cell-based assays for drug screening.
Condreay JP, Ames RS, Hassan NJ, Kost TA, Merrihew RV, Mossakowska DE, Pountney DJ, Romanos MA. Condreay JP, et al. Among authors: merrihew rv. Adv Virus Res. 2006;68:255-86. doi: 10.1016/S0065-3527(06)68007-X. Adv Virus Res. 2006. PMID: 16997014 Review. No abstract available.
The application of BacMam technology in nuclear receptor drug discovery.
Boudjelal M, Mason SJ, Katso RM, Fleming JM, Parham JH, Condreay JP, Merrihew RV, Cairns WJ. Boudjelal M, et al. Among authors: merrihew rv. Biotechnol Annu Rev. 2005;11:101-25. doi: 10.1016/S1387-2656(05)11003-5. Biotechnol Annu Rev. 2005. PMID: 16216775 Review.
15 results