Garnsey MR - Search Results

1

Asymmetric total synthesis of (+)- and (-)-clusianone and (+)- and (-)-clusianone methyl enol ether via ACC alkylation and evaluation of their anti-HIV activity.

Garnsey MR, Matous JA, Kwiek JJ, Coltart DM. Garnsey MR, et al. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2406-9. doi: 10.1016/j.bmcl.2011.02.074. Epub 2011 Feb 23. Bioorg Med Chem Lett. 2011. PMID: 21414776 Free PMC article.

2

Development of a strategy for the asymmetric synthesis of polycyclic polyprenylated acylphloroglucinols via N-amino cyclic carbamate hydrazones: application to the total synthesis of (+)-clusianone.

Garnsey MR, Lim D, Yost JM, Coltart DM. Garnsey MR, et al. Org Lett. 2010 Nov 19;12(22):5234-7. doi: 10.1021/ol1022728. Epub 2010 Oct 26. Org Lett. 2010. PMID: 20977254

3

Direct carbon-carbon bond formation via soft enolization: a biomimetic asymmetric Mannich reaction of phenylacetate thioesters.

Kohler MC, Yost JM, Garnsey MR, Coltart DM. Kohler MC, et al. Among authors: garnsey mr. Org Lett. 2010 Aug 6;12(15):3376-9. doi: 10.1021/ol101152b. Org Lett. 2010. PMID: 20608684

4

Direct carbon-carbon bond formation via reductive soft enolization: a kinetically controlled syn-aldol addition of α-halo thioesters and enolizable aldehydes.

Sauer SJ, Garnsey MR, Coltart DM. Sauer SJ, et al. Among authors: garnsey mr. J Am Chem Soc. 2010 Oct 13;132(40):13997-9. doi: 10.1021/ja1057407. J Am Chem Soc. 2010. PMID: 20849119

5

Design and optimization of selective azaindole amide M1 positive allosteric modulators.

Davoren JE, O'Neil SV, Anderson DP, Brodney MA, Chenard L, Dlugolenski K, Edgerton JR, Green M, Garnsey M, Grimwood S, Harris AR, Kauffman GW, LaChapelle E, Lazzaro JT, Lee CW, Lotarski SM, Nason DM, Obach RS, Reinhart V, Salomon-Ferrer R, Steyn SJ, Webb D, Yan J, Zhang L. Davoren JE, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):650-655. doi: 10.1016/j.bmcl.2015.11.053. Epub 2015 Nov 17. Bioorg Med Chem Lett. 2016. PMID: 26631313

6

Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects.

Davoren JE, Lee CW, Garnsey M, Brodney MA, Cordes J, Dlugolenski K, Edgerton JR, Harris AR, Helal CJ, Jenkinson S, Kauffman GW, Kenakin TP, Lazzaro JT, Lotarski SM, Mao Y, Nason DM, Northcott C, Nottebaum L, O'Neil SV, Pettersen B, Popiolek M, Reinhart V, Salomon-Ferrer R, Steyn SJ, Webb D, Zhang L, Grimwood S. Davoren JE, et al. J Med Chem. 2016 Jul 14;59(13):6313-28. doi: 10.1021/acs.jmedchem.6b00544. Epub 2016 Jul 1. J Med Chem. 2016. PMID: 27275946

7

Transforming Benzylic Amines into Diarylmethanes: Cross-Couplings of Benzylic Pyridinium Salts via C-N Bond Activation.

Liao J, Guan W, Boscoe BP, Tucker JW, Tomlin JW, Garnsey MR, Watson MP. Liao J, et al. Among authors: garnsey mr. Org Lett. 2018 May 18;20(10):3030-3033. doi: 10.1021/acs.orglett.8b01062. Epub 2018 May 10. Org Lett. 2018. PMID: 29745674 Free PMC article.

8

Deaminative Reductive Cross-Electrophile Couplings of Alkylpyridinium Salts and Aryl Bromides.

Liao J, Basch CH, Hoerrner ME, Talley MR, Boscoe BP, Tucker JW, Garnsey MR, Watson MP. Liao J, et al. Among authors: garnsey mr. Org Lett. 2019 Apr 19;21(8):2941-2946. doi: 10.1021/acs.orglett.9b01014. Epub 2019 Mar 27. Org Lett. 2019. PMID: 30917282 Free PMC article.

9

Short Enantioselective Total Syntheses of Cheloviolenes A and B and Dendrillolide C via Convergent Fragment Coupling Using a Tertiary Carbon Radical.

Garnsey MR, Slutskyy Y, Jamison CR, Zhao P, Lee J, Rhee YH, Overman LE. Garnsey MR, et al. J Org Chem. 2018 Jul 6;83(13):6958-6976. doi: 10.1021/acs.joc.7b02458. Epub 2017 Nov 13. J Org Chem. 2018. PMID: 29130687

10

Design and Synthesis of γ- and δ-Lactam M₁ Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M₁-Selective PAM with Weak Agonist Activity.

Davoren JE, Garnsey M, Pettersen B, Brodney MA, Edgerton JR, Fortin JP, Grimwood S, Harris AR, Jenkinson S, Kenakin T, Lazzaro JT, Lee CW, Lotarski SM, Nottebaum L, O'Neil SV, Popiolek M, Ramsey S, Steyn SJ, Thorn CA, Zhang L, Webb D. Davoren JE, et al. J Med Chem. 2017 Aug 10;60(15):6649-6663. doi: 10.1021/acs.jmedchem.7b00597. Epub 2017 Jul 26. J Med Chem. 2017. PMID: 28598634

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