Chung NN - Search Results

1

Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.

Ballet S, Feytens D, Buysse K, Chung NN, Lemieux C, Tumati S, Keresztes A, Van Duppen J, Lai J, Varga E, Porreca F, Schiller PW, Vanden Broeck J, Tourwé D. Ballet S, et al. Among authors: chung nn. J Med Chem. 2011 Apr 14;54(7):2467-76. doi: 10.1021/jm1016285. Epub 2011 Mar 17. J Med Chem. 2011. PMID: 21413804 Free PMC article.

2

A novel cyclic enkephalin analogue with potent opioid antagonist activity.

Weltrowska G, Lu Y, Lemieux C, Chung NN, Schiller PW. Weltrowska G, et al. Among authors: chung nn. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4731-3. doi: 10.1016/j.bmcl.2004.06.077. Bioorg Med Chem Lett. 2004. PMID: 15324897

3

A new structural motif for mu-opioid antagonists.

Van den Eynde I, Laus G, Schiller PW, Kosson P, Chung NN, Lipkowski AW, Tourwé D. Van den Eynde I, et al. Among authors: chung nn. J Med Chem. 2005 May 19;48(10):3644-8. doi: 10.1021/jm0491795. J Med Chem. 2005. PMID: 15887972

4

Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opioid antagonists.

Lu Y, Lum TK, Leow Augustine YW, Weltrowska G, Nguyen TM, Lemieux C, Chung NN, Schiller PW. Lu Y, et al. Among authors: chung nn. J Med Chem. 2006 Aug 24;49(17):5382-5. doi: 10.1021/jm060369k. J Med Chem. 2006. PMID: 16913729

5

Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2).

Fichna J, do-Rego JC, Chung NN, Lemieux C, Schiller PW, Poels J, Broeck JV, Costentin J, Janecka A. Fichna J, et al. Among authors: chung nn. J Med Chem. 2007 Feb 8;50(3):512-20. doi: 10.1021/jm060998u. J Med Chem. 2007. PMID: 17266203

6

Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility.

Ballet S, Misicka A, Kosson P, Lemieux C, Chung NN, Schiller PW, Lipkowski AW, Tourwé D. Ballet S, et al. Among authors: chung nn. J Med Chem. 2008 Apr 24;51(8):2571-4. doi: 10.1021/jm701404s. Epub 2008 Mar 28. J Med Chem. 2008. PMID: 18370374

7

Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp].

Ghosh A, Luo J, Liu C, Weltrowska G, Lemieux C, Chung NN, Lu Y, Schiller PW. Ghosh A, et al. Among authors: chung nn. J Med Chem. 2008 Sep 25;51(18):5866-70. doi: 10.1021/jm8004702. J Med Chem. 2008. PMID: 18800771 Free PMC article.

8

Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1).

Berezowska I, Chung NN, Lemieux C, Wilkes BC, Schiller PW. Berezowska I, et al. Among authors: chung nn. J Med Chem. 2009 Nov 12;52(21):6941-5. doi: 10.1021/jm9004913. J Med Chem. 2009. PMID: 19827750 Free PMC article.

9

Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at the δ opioid receptor. Discovery of two highly potent and selective δ opioid agonists.

Berezowska I, Lemieux C, Chung NN, Ding J, Schiller PW. Berezowska I, et al. Among authors: chung nn. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1899-902. doi: 10.1016/j.bmcl.2012.01.063. Epub 2012 Jan 28. Bioorg Med Chem Lett. 2012. PMID: 22325949 Free PMC article.

10

Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.

Novoa A, Van Dorpe S, Wynendaele E, Spetea M, Bracke N, Stalmans S, Betti C, Chung NN, Lemieux C, Zuegg J, Cooper MA, Tourwé D, De Spiegeleer B, Schiller PW, Ballet S. Novoa A, et al. Among authors: chung nn. J Med Chem. 2012 Nov 26;55(22):9549-61. doi: 10.1021/jm3008079. Epub 2012 Nov 12. J Med Chem. 2012. PMID: 23102273 Free PMC article.

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