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Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition.
Juillerat A, Lewit-Bentley A, Guillotte M, Gangnard S, Hessel A, Baron B, Vigan-Womas I, England P, Mercereau-Puijalon O, Bentley GA. Juillerat A, et al. Among authors: gangnard s. Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5243-8. doi: 10.1073/pnas.1018692108. Epub 2011 Mar 14. Proc Natl Acad Sci U S A. 2011. PMID: 21402930 Free PMC article.
Biochemical and biophysical characterisation of DBL1alpha1-varO, the rosetting domain of PfEMP1 from the VarO line of Plasmodium falciparum.
Juillerat A, Igonet S, Vigan-Womas I, Guillotte M, Gangnard S, Faure G, Baron B, Raynal B, Mercereau-Puijalon O, Bentley GA. Juillerat A, et al. Among authors: gangnard s. Mol Biochem Parasitol. 2010 Apr;170(2):84-92. doi: 10.1016/j.molbiopara.2009.12.008. Epub 2010 Jan 4. Mol Biochem Parasitol. 2010. PMID: 20045435
Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA.
Srivastava A, Gangnard S, Round A, Dechavanne S, Juillerat A, Raynal B, Faure G, Baron B, Ramboarina S, Singh SK, Belrhali H, England P, Lewit-Bentley A, Scherf A, Bentley GA, Gamain B. Srivastava A, et al. Among authors: gangnard s. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4884-9. doi: 10.1073/pnas.1000951107. Epub 2010 Mar 1. Proc Natl Acad Sci U S A. 2010. PMID: 20194779 Free PMC article.
Var2CSA minimal CSA binding region is located within the N-terminal region.
Srivastava A, Gangnard S, Dechavanne S, Amirat F, Lewit Bentley A, Bentley GA, Gamain B. Srivastava A, et al. Among authors: gangnard s. PLoS One. 2011;6(5):e20270. doi: 10.1371/journal.pone.0020270. Epub 2011 May 19. PLoS One. 2011. PMID: 21625526 Free PMC article.
Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA.
Dorin-Semblat D, Tétard M, Claës A, Semblat JP, Dechavanne S, Fourati Z, Hamelin R, Armand F, Matesic G, Nunes-Silva S, Srivastava A, Gangnard S, Lopez-Rubio JJ, Moniatte M, Doerig C, Scherf A, Gamain B. Dorin-Semblat D, et al. Among authors: gangnard s. PLoS Biol. 2019 Jun 10;17(6):e3000308. doi: 10.1371/journal.pbio.3000308. eCollection 2019 Jun. PLoS Biol. 2019. PMID: 31181082 Free PMC article.
23 results