Xu F - Search Results

1

Structure of an agonist-bound human A2A adenosine receptor.

Xu F, Wu H, Katritch V, Han GW, Jacobson KA, Gao ZG, Cherezov V, Stevens RC. Xu F, et al. Science. 2011 Apr 15;332(6027):322-7. doi: 10.1126/science.1202793. Epub 2011 Mar 10. Science. 2011. PMID: 21393508 Free PMC article.

2

Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor.

Deflorian F, Kumar TS, Phan K, Gao ZG, Xu F, Wu H, Katritch V, Stevens RC, Jacobson KA. Deflorian F, et al. Among authors: xu f. J Med Chem. 2012 Jan 12;55(1):538-52. doi: 10.1021/jm201461q. Epub 2011 Dec 12. J Med Chem. 2012. PMID: 22104008 Free PMC article.

3

Structural basis for allosteric regulation of GPCRs by sodium ions.

Liu W, Chun E, Thompson AA, Chubukov P, Xu F, Katritch V, Han GW, Roth CB, Heitman LH, IJzerman AP, Cherezov V, Stevens RC. Liu W, et al. Among authors: xu f. Science. 2012 Jul 13;337(6091):232-6. doi: 10.1126/science.1219218. Science. 2012. PMID: 22798613 Free PMC article.

4

Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases.

Xu F, Liu W, Hanson MA, Stevens RC, Cherezov V. Xu F, et al. Cryst Growth Des. 2011 Apr 6;11(4):1193-1201. doi: 10.1021/cg101385e. Cryst Growth Des. 2011. PMID: 21660116 Free PMC article.

5

Trapping small caffeine in a large GPCR pocket.

Xu F, Stevens RC. Xu F, et al. Structure. 2011 Sep 7;19(9):1204-7. doi: 10.1016/j.str.2011.08.007. Structure. 2011. PMID: 21893281 Free PMC article.

6

Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.

Tosh DK, Phan K, Gao ZG, Gakh AA, Xu F, Deflorian F, Abagyan R, Stevens RC, Jacobson KA, Katritch V. Tosh DK, et al. Among authors: xu f. J Med Chem. 2012 May 10;55(9):4297-308. doi: 10.1021/jm300095s. Epub 2012 Apr 30. J Med Chem. 2012. PMID: 22486652 Free PMC article.

7

Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors.

Chun E, Thompson AA, Liu W, Roth CB, Griffith MT, Katritch V, Kunken J, Xu F, Cherezov V, Hanson MA, Stevens RC. Chun E, et al. Among authors: xu f. Structure. 2012 Jun 6;20(6):967-76. doi: 10.1016/j.str.2012.04.010. Structure. 2012. PMID: 22681902 Free PMC article.

8

The importance of ligands for G protein-coupled receptor stability.

Zhang X, Stevens RC, Xu F. Zhang X, et al. Among authors: xu f. Trends Biochem Sci. 2015 Feb;40(2):79-87. doi: 10.1016/j.tibs.2014.12.005. Epub 2015 Jan 15. Trends Biochem Sci. 2015. PMID: 25601764

9

Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.

Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W, Tao H, Xu F. Zhang X, et al. Among authors: xu f. Nat Commun. 2017 May 17;8:15383. doi: 10.1038/ncomms15383. Nat Commun. 2017. PMID: 28513578 Free PMC article.

10

Crystal structure of the Frizzled 4 receptor in a ligand-free state.

Yang S, Wu Y, Xu TH, de Waal PW, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, Dong S, Harikumar KG, Miller LJ, Katritch V, Xu HE, Shui W, Stevens RC, Melcher K, Zhao S, Xu F. Yang S, et al. Among authors: xu he, xu th, xu f. Nature. 2018 Aug;560(7720):666-670. doi: 10.1038/s41586-018-0447-x. Epub 2018 Aug 22. Nature. 2018. PMID: 30135577

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