Deshaies RJ - Search Results

1

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways.

Chou TF, Brown SJ, Minond D, Nordin BE, Li K, Jones AC, Chase P, Porubsky PR, Stoltz BM, Schoenen FJ, Patricelli MP, Hodder P, Rosen H, Deshaies RJ. Chou TF, et al. Among authors: deshaies rj. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9. doi: 10.1073/pnas.1015312108. Epub 2011 Mar 7. Proc Natl Acad Sci U S A. 2011. PMID: 21383145 Free PMC article.

2

Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein.

Lyapina SA, Correll CC, Kipreos ET, Deshaies RJ. Lyapina SA, et al. Among authors: deshaies rj. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7451-6. doi: 10.1073/pnas.95.13.7451. Proc Natl Acad Sci U S A. 1998. PMID: 9636170 Free PMC article.

3

Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation.

Lipford JR, Deshaies RJ. Lipford JR, et al. Among authors: deshaies rj. Nat Cell Biol. 2003 Oct;5(10):845-50. doi: 10.1038/ncb1003-845. Nat Cell Biol. 2003. PMID: 14523392

4

Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain.

Verma R, Peters NR, D'Onofrio M, Tochtrop GP, Sakamoto KM, Varadan R, Zhang M, Coffino P, Fushman D, Deshaies RJ, King RW. Verma R, et al. Among authors: deshaies rj. Science. 2004 Oct 1;306(5693):117-20. doi: 10.1126/science.1100946. Science. 2004. PMID: 15459393 Free article.

5

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.

Alexandru G, Graumann J, Smith GT, Kolawa NJ, Fang R, Deshaies RJ. Alexandru G, et al. Among authors: deshaies rj. Cell. 2008 Sep 5;134(5):804-16. doi: 10.1016/j.cell.2008.06.048. Cell. 2008. PMID: 18775313 Free PMC article.

6

RING domain E3 ubiquitin ligases.

Deshaies RJ, Joazeiro CA. Deshaies RJ, et al. Annu Rev Biochem. 2009;78:399-434. doi: 10.1146/annurev.biochem.78.101807.093809. Annu Rev Biochem. 2009. PMID: 19489725 Review.

7

Physiologically relevant and portable tandem ubiquitin-binding domain stabilizes polyubiquitylated proteins.

Tyrrell A, Flick K, Kleiger G, Zhang H, Deshaies RJ, Kaiser P. Tyrrell A, et al. Among authors: deshaies rj. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19796-801. doi: 10.1073/pnas.1010648107. Epub 2010 Nov 1. Proc Natl Acad Sci U S A. 2010. PMID: 21041680 Free PMC article.

8

Cdc48/p97 mediates UV-dependent turnover of RNA Pol II.

Verma R, Oania R, Fang R, Smith GT, Deshaies RJ. Verma R, et al. Among authors: deshaies rj. Mol Cell. 2011 Jan 7;41(1):82-92. doi: 10.1016/j.molcel.2010.12.017. Mol Cell. 2011. PMID: 21211725 Free PMC article.

9

Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system.

Chou TF, Deshaies RJ. Chou TF, et al. Among authors: deshaies rj. J Biol Chem. 2011 May 13;286(19):16546-54. doi: 10.1074/jbc.M110.215319. Epub 2011 Feb 22. J Biol Chem. 2011. PMID: 21343295 Free PMC article.

10

Development of p97 AAA ATPase inhibitors.

Chou TF, Deshaies RJ. Chou TF, et al. Among authors: deshaies rj. Autophagy. 2011 Sep;7(9):1091-2. doi: 10.4161/auto.7.9.16489. Epub 2011 Sep 1. Autophagy. 2011. PMID: 21606684 Free PMC article.

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