Chou TF - Search Results

1

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways.

Chou TF, Brown SJ, Minond D, Nordin BE, Li K, Jones AC, Chase P, Porubsky PR, Stoltz BM, Schoenen FJ, Patricelli MP, Hodder P, Rosen H, Deshaies RJ. Chou TF, et al. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9. doi: 10.1073/pnas.1015312108. Epub 2011 Mar 7. Proc Natl Acad Sci U S A. 2011. PMID: 21383145 Free PMC article.

2

Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system.

Chou TF, Deshaies RJ. Chou TF, et al. J Biol Chem. 2011 May 13;286(19):16546-54. doi: 10.1074/jbc.M110.215319. Epub 2011 Feb 22. J Biol Chem. 2011. PMID: 21343295 Free PMC article.

3

Development of p97 AAA ATPase inhibitors.

Chou TF, Deshaies RJ. Chou TF, et al. Autophagy. 2011 Sep;7(9):1091-2. doi: 10.4161/auto.7.9.16489. Epub 2011 Sep 1. Autophagy. 2011. PMID: 21606684 Free PMC article.

4

Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase.

Chou TF, Li K, Frankowski KJ, Schoenen FJ, Deshaies RJ. Chou TF, et al. ChemMedChem. 2013 Feb;8(2):297-312. doi: 10.1002/cmdc.201200520. Epub 2013 Jan 11. ChemMedChem. 2013. PMID: 23316025 Free PMC article.

5

Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.

Chou TF, Bulfer SL, Weihl CC, Li K, Lis LG, Walters MA, Schoenen FJ, Lin HJ, Deshaies RJ, Arkin MR. Chou TF, et al. J Mol Biol. 2014 Jul 29;426(15):2886-99. doi: 10.1016/j.jmb.2014.05.022. Epub 2014 May 27. J Mol Biol. 2014. PMID: 24878061 Free PMC article.

6

Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging.

Sapir A, Tsur A, Koorman T, Ching K, Mishra P, Bardenheier A, Podolsky L, Bening-Abu-Shach U, Boxem M, Chou TF, Broday L, Sternberg PW. Sapir A, et al. Among authors: chou tf. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):E3880-9. doi: 10.1073/pnas.1414748111. Epub 2014 Sep 3. Proc Natl Acad Sci U S A. 2014. PMID: 25187565 Free PMC article.

7

Evaluating p97 inhibitor analogues for their domain selectivity and potency against the p97-p47 complex.

Fang CJ, Gui L, Zhang X, Moen DR, Li K, Frankowski KJ, Lin HJ, Schoenen FJ, Chou TF. Fang CJ, et al. Among authors: chou tf. ChemMedChem. 2015 Jan;10(1):52-6. doi: 10.1002/cmdc.201402420. Epub 2014 Nov 6. ChemMedChem. 2015. PMID: 25377500 Free PMC article.

8

Altered cofactor regulation with disease-associated p97/VCP mutations.

Zhang X, Gui L, Zhang X, Bulfer SL, Sanghez V, Wong DE, Lee Y, Lehmann L, Lee JS, Shih PY, Lin HJ, Iacovino M, Weihl CC, Arkin MR, Wang Y, Chou TF. Zhang X, et al. Among authors: chou tf. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1705-14. doi: 10.1073/pnas.1418820112. Epub 2015 Mar 16. Proc Natl Acad Sci U S A. 2015. PMID: 25775548 Free PMC article.

9

Evaluating p97 Inhibitor Analogues for Potency against p97-p37 and p97-Npl4-Ufd1 Complexes.

Gui L, Zhang X, Li K, Frankowski KJ, Li S, Wong DE, Moen DR, Porubsky PR, Lin HJ, Schoenen FJ, Chou TF. Gui L, et al. Among authors: chou tf. ChemMedChem. 2016 May 6;11(9):953-7. doi: 10.1002/cmdc.201600036. Epub 2016 Apr 4. ChemMedChem. 2016. PMID: 27043824 Free PMC article.

10

Discovery of an Inhibitor of the Proteasome Subunit Rpn11.

Perez C, Li J, Parlati F, Rouffet M, Ma Y, Mackinnon AL, Chou TF, Deshaies RJ, Cohen SM. Perez C, et al. Among authors: chou tf. J Med Chem. 2017 Feb 23;60(4):1343-1361. doi: 10.1021/acs.jmedchem.6b01379. Epub 2017 Feb 13. J Med Chem. 2017. PMID: 28191850 Free PMC article.

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