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Retention of the in vitro radiosensitizing potential of gemcitabine under anoxic conditions, in p53 wild-type and p53-deficient non-small-cell lung carcinoma cells.
Wouters A, Pauwels B, Lambrechts HA, Pattyn GG, Ides J, Baay M, Meijnders P, Peeters M, Vermorken JB, Lardon F. Wouters A, et al. Among authors: baay m. Int J Radiat Oncol Biol Phys. 2011 Jun 1;80(2):558-66. doi: 10.1016/j.ijrobp.2010.12.051. Epub 2011 Mar 4. Int J Radiat Oncol Biol Phys. 2011. PMID: 21377279
The radiosensitising effect of gemcitabine and its main metabolite dFdU under low oxygen conditions is in vitro not dependent on functional HIF-1 protein.
Wouters A, Pauwels B, Burrows N, Baay M, Deschoolmeester V, Vu TN, Laukens K, Meijnders P, Van Gestel D, Williams KJ, Van den Weyngaert D, Vermorken JB, Pauwels P, Peeters M, Lardon F. Wouters A, et al. Among authors: baay m. BMC Cancer. 2014 Aug 16;14:594. doi: 10.1186/1471-2407-14-594. BMC Cancer. 2014. PMID: 25128202 Free PMC article.
111 results