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The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.
Barroso E, Rodríguez-Calvo R, Serrano-Marco L, Astudillo AM, Balsinde J, Palomer X, Vázquez-Carrera M. Barroso E, et al. Among authors: serrano marco l. Endocrinology. 2011 May;152(5):1848-59. doi: 10.1210/en.2010-1468. Epub 2011 Mar 1. Endocrinology. 2011. PMID: 21363937 Free article.
Targeting PPARβ/δ for the treatment of type 2 diabetes mellitus.
Salvadó L, Serrano-Marco L, Barroso E, Palomer X, Vázquez-Carrera M. Salvadó L, et al. Among authors: serrano marco l. Expert Opin Ther Targets. 2012 Feb;16(2):209-23. doi: 10.1517/14728222.2012.658370. Epub 2012 Jan 27. Expert Opin Ther Targets. 2012. PMID: 22280315 Review.
TNF-α inhibits PPARβ/δ activity and SIRT1 expression through NF-κB in human adipocytes.
Serrano-Marco L, Chacón MR, Maymó-Masip E, Barroso E, Salvadó L, Wabitsch M, Garrido-Sánchez L, Tinahones FJ, Palomer X, Vendrell J, Vázquez-Carrera M. Serrano-Marco L, et al. Biochim Biophys Acta. 2012 Sep;1821(9):1177-85. doi: 10.1016/j.bbalip.2012.05.006. Epub 2012 Jun 7. Biochim Biophys Acta. 2012. PMID: 22683888 Clinical Trial.