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Canakinumab (ACZ885, a fully human IgG1 anti-IL-1β mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS).
Kuemmerle-Deschner JB, Ramos E, Blank N, Roesler J, Felix SD, Jung T, Stricker K, Chakraborty A, Tannenbaum S, Wright AM, Rordorf C. Kuemmerle-Deschner JB, et al. Among authors: jung t. Arthritis Res Ther. 2011 Feb 28;13(1):R34. doi: 10.1186/ar3266. Arthritis Res Ther. 2011. PMID: 21356079 Free PMC article. Clinical Trial.
The human anti-IL-1 beta monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis.
Alten R, Gram H, Joosten LA, van den Berg WB, Sieper J, Wassenberg S, Burmester G, van Riel P, Diaz-Lorente M, Bruin GJ, Woodworth TG, Rordorf C, Batard Y, Wright AM, Jung T. Alten R, et al. Among authors: jung t. Arthritis Res Ther. 2008;10(3):R67. doi: 10.1186/ar2438. Epub 2008 Jun 5. Arthritis Res Ther. 2008. PMID: 18534016 Free PMC article. Clinical Trial.
MRP8 and MRP14, phagocyte-specific danger signals, are sensitive biomarkers of disease activity in cryopyrin-associated periodic syndromes.
Wittkowski H, Kuemmerle-Deschner JB, Austermann J, Holzinger D, Goldbach-Mansky R, Gramlich K, Lohse P, Jung T, Roth J, Benseler SM, Foell D. Wittkowski H, et al. Among authors: jung t. Ann Rheum Dis. 2011 Dec;70(12):2075-2081. doi: 10.1136/ard.2011.152496. Epub 2011 Sep 8. Ann Rheum Dis. 2011. PMID: 21908452 Free PMC article.
2,039 results