Allen J - Search Results

1

A "click and activate" approach in one-pot synthesis of a triazolyl-pyridazinone library.

Qian W, Winternheimer D, Allen J. Qian W, et al. Among authors: allen j. Org Lett. 2011 Apr 1;13(7):1682-5. doi: 10.1021/ol200183b. Epub 2011 Feb 25. Org Lett. 2011. PMID: 21351762

2

Palladium-catalyzed one-pot synthesis of 2-alkyl-2-arylcyanoacetates.

Wang X, Guram A, Bunel E, Cao GQ, Allen JR, Faul MM. Wang X, et al. J Org Chem. 2008 Feb 15;73(4):1643-5. doi: 10.1021/jo7024338. Epub 2008 Jan 16. J Org Chem. 2008. PMID: 18197689

3

One-pot synthesis of 3-triazolyl-2-iminochromenes via a catalytic three component cascade reaction.

Qian W, Amegadzie A, Winternheimer D, Allen J. Qian W, et al. Among authors: allen j. Org Lett. 2013 Jun 21;15(12):2986-9. doi: 10.1021/ol401151z. Epub 2013 Jun 10. Org Lett. 2013. PMID: 23751086

4

Copper-catalyzed domino cycloaddition/C-N coupling/cyclization/(C-H arylation): an efficient three-component synthesis of nitrogen polyheterocycles.

Qian W, Wang H, Allen J. Qian W, et al. Among authors: allen j. Angew Chem Int Ed Engl. 2013 Oct 11;52(42):10992-6. doi: 10.1002/anie.201305970. Epub 2013 Sep 6. Angew Chem Int Ed Engl. 2013. PMID: 24014265

5

Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease.

Chen JJ, Qian W, Biswas K, Yuan C, Amegadzie A, Liu Q, Nixey T, Zhu J, Ncube M, Rzasa RM, Chavez F Jr, Chen N, DeMorin F, Rumfelt S, Tegley CM, Allen JR, Hitchcock S, Hungate R, Bartberger MD, Zalameda L, Liu Y, McCarter JD, Zhang J, Zhu L, Babu-Khan S, Luo Y, Bradley J, Wen PH, Reid DL, Koegler F, Dean C Jr, Hickman D, Correll TL, Williamson T, Wood S. Chen JJ, et al. Among authors: allen jr. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6447-54. doi: 10.1016/j.bmcl.2013.09.041. Epub 2013 Sep 29. Bioorg Med Chem Lett. 2013. PMID: 24139583

6

The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement.

Frohn M, Liu L, Siegmund AC, Qian W, Amegadzie A, Chen N, Tan H, Hickman D, Wood S, Wen PH, Bartberger MD, Whittington DA, Allen JR, Bourbeau MP. Frohn M, et al. Bioorg Med Chem Lett. 2020 Jul 15;30(14):127240. doi: 10.1016/j.bmcl.2020.127240. Epub 2020 May 4. Bioorg Med Chem Lett. 2020. PMID: 32527542

7

Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation.

Tegley CM, Viswanadhan VN, Biswas K, Frohn MJ, Peterkin TA, Chang C, Bürli RW, Dao JH, Veith H, Rogers N, Yoder SC, Biddlecome G, Tagari P, Allen JR, Hungate RW. Tegley CM, et al. Among authors: allen jr. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3925-8. doi: 10.1016/j.bmcl.2008.06.031. Epub 2008 Jun 13. Bioorg Med Chem Lett. 2008. PMID: 18579373

8

Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1alpha prolyl hydroxylase-2 inhibitors.

Frohn M, Viswanadhan V, Pickrell AJ, Golden JE, Muller KM, Bürli RW, Biddlecome G, Yoder SC, Rogers N, Dao JH, Hungate R, Allen JR. Frohn M, et al. Among authors: allen jr. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5023-6. doi: 10.1016/j.bmcl.2008.08.012. Epub 2008 Aug 9. Bioorg Med Chem Lett. 2008. PMID: 18755588

9

Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity.

Murray JK, Balan C, Allgeier AM, Kasparian A, Viswanadhan V, Wilde C, Allen JR, Yoder SC, Biddlecome G, Hungate RW, Miranda LP. Murray JK, et al. J Comb Chem. 2010 Sep 13;12(5):676-86. doi: 10.1021/cc100073a. J Comb Chem. 2010. PMID: 20666436

10

Discovery of potent, orally bioavailable phthalazinone bradykinin B1 receptor antagonists.

Biswas K, Peterkin TA, Bryan MC, Arik L, Lehto SG, Sun H, Hsieh FY, Xu C, Fremeau RT, Allen JR. Biswas K, et al. J Med Chem. 2011 Oct 27;54(20):7232-46. doi: 10.1021/jm200808v. Epub 2011 Sep 26. J Med Chem. 2011. PMID: 21902230

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