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Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.
Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD. Guevara-Aguirre J, et al. Among authors: saavedra j. Sci Transl Med. 2011 Feb 16;3(70):70ra13. doi: 10.1126/scitranslmed.3001845. Sci Transl Med. 2011. PMID: 21325617 Free PMC article.
GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity.
Guevara-Aguirre J, Rosenbloom AL, Balasubramanian P, Teran E, Guevara-Aguirre M, Guevara C, Procel P, Alfaras I, De Cabo R, Di Biase S, Narvaez L, Saavedra J, Longo VD. Guevara-Aguirre J, et al. Among authors: saavedra j. J Clin Endocrinol Metab. 2015 Jul;100(7):2589-96. doi: 10.1210/jc.2015-1678. Epub 2015 May 18. J Clin Endocrinol Metab. 2015. PMID: 25985182 Free PMC article.
Assessing insulin sensitivity and resistance in syndromes of severe short stature.
Guevara-Aguirre J, Teran E, Lescano D, Guevara C, Guevara A, Saavedra J, Procel P, Wasserfall C, Gavilanes AWD. Guevara-Aguirre J, et al. Among authors: saavedra j. Growth Horm IGF Res. 2020 Aug-Oct;53-54:101339. doi: 10.1016/j.ghir.2020.101339. Epub 2020 Jul 28. Growth Horm IGF Res. 2020. PMID: 32763832
Cancer in Ecuadorian subjects with Laron syndrome (ELS).
Guevara-Aguirre J, Peña G, Pazmiño G, Acosta W, Saavedra J, Lescano D, Guevara A, Gavilanes AWD. Guevara-Aguirre J, et al. Among authors: saavedra j. Endocr Relat Cancer. 2023 May 11;30(6):e220389. doi: 10.1530/ERC-22-0389. Print 2023 Jun 1. Endocr Relat Cancer. 2023. PMID: 36971780
Cancer in growth hormone excess and growth hormone deficit.
Guevara-Aguirre J, Peña G, Acosta W, Pazmiño G, Saavedra J, Soto L, Lescano D, Guevara A, Gavilanes AWD. Guevara-Aguirre J, et al. Among authors: saavedra j. Endocr Relat Cancer. 2023 Aug 14;30(10):e220402. doi: 10.1530/ERC-22-0402. Print 2023 Oct 1. Endocr Relat Cancer. 2023. PMID: 37428642 Review.
Inbreeding and Gallbladder Cancer Risk: Homozygosity Associations Adjusted for Indigenous American Ancestry, BMI, and Genetic Risk of Gallstone Disease.
Ceballos F, Boekstegers F, Scherer D, Barahona Ponce C, Marcelain K, Gárate-Calderón V, Waldenberger M, Morales E, Rojas A, Munoz C, Retamales J, de Toro G, Vera Kortmann A, Barajas O, Rivera MT, Cortés A, Loader D, Saavedra J, Gutiérrez L, Ortega A, Bertrán ME, Bartolotti L, Gabler F, Campos M, Alvarado J, Moisán F, Spencer L, Nervi B, Carvajal-Hausdorf D, Losada H, Almau M, Fernández P, Olloquequi J, Salinas P, Lorenzo Bermejo J. Ceballos F, et al. Among authors: saavedra j. Cancers (Basel). 2024 Dec 17;16(24):4195. doi: 10.3390/cancers16244195. Cancers (Basel). 2024. PMID: 39766094 Free PMC article.
1,180 results