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Synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues and their effects on monoamine uptake, nicotinic acetylcholine receptor function, and behavioral effects of nicotine.
Carroll FI, Muresan AZ, Blough BE, Navarro HA, Mascarella SW, Eaton JB, Huang X, Damaj MI, Lukas RJ. Carroll FI, et al. Among authors: lukas rj. J Med Chem. 2011 Mar 10;54(5):1441-8. doi: 10.1021/jm1014555. Epub 2011 Feb 14. J Med Chem. 2011. PMID: 21319801 Free PMC article.
Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.
Yu LF, Eaton JB, Fedolak A, Zhang HK, Hanania T, Brunner D, Lukas RJ, Kozikowski AP. Yu LF, et al. Among authors: lukas rj. J Med Chem. 2012 Nov 26;55(22):9998-10009. doi: 10.1021/jm301177j. Epub 2012 Nov 2. J Med Chem. 2012. PMID: 23092294 Free PMC article.
Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II.
Zhang HK, Yu LF, Eaton JB, Whiteaker P, Onajole OK, Hanania T, Brunner D, Lukas RJ, Kozikowski AP. Zhang HK, et al. Among authors: lukas rj. J Med Chem. 2013 Jul 11;56(13):5495-504. doi: 10.1021/jm400510u. Epub 2013 Jun 26. J Med Chem. 2013. PMID: 23734673 Free PMC article.
Bupropion and bupropion analogs as treatments for CNS disorders.
Carroll FI, Blough BE, Mascarella SW, Navarro HA, Lukas RJ, Damaj MI. Carroll FI, et al. Among authors: lukas rj. Adv Pharmacol. 2014;69:177-216. doi: 10.1016/B978-0-12-420118-7.00005-6. Adv Pharmacol. 2014. PMID: 24484978 Review.
169 results