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Genetic bases of the temperature-sensitive phenotype of a master donor virus used in live attenuated influenza vaccines: A/Leningrad/134/17/57 (H2N2).
Isakova-Sivak I, Chen LM, Matsuoka Y, Voeten JT, Kiseleva I, Heldens JG, den Bosch Hv, Klimov A, Rudenko L, Cox NJ, Donis RO. Isakova-Sivak I, et al. Among authors: heldens jg. Virology. 2011 Apr 10;412(2):297-305. doi: 10.1016/j.virol.2011.01.004. Epub 2011 Feb 18. Virology. 2011. PMID: 21315402 Free article.
Master donor viruses A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortants used in live attenuated influenza vaccine (LAIV) do not display neurovirulent properties in a mouse model.
Voeten JT, Kiseleva IV, Glansbeek HL, Basten SM, Drieszen-van der Cruijsen SK, Rudenko LG, van den Bosch H, Heldens JG. Voeten JT, et al. Among authors: heldens jg. Arch Virol. 2010 Sep;155(9):1391-9. doi: 10.1007/s00705-010-0719-8. Epub 2010 Jun 10. Arch Virol. 2010. PMID: 20532926 Free article.
Comparative immunogenicity and cross-clade protective efficacy of mammalian cell-grown inactivated and live attenuated H5N1 reassortant vaccines in ferrets.
Gustin KM, Maines TR, Belser JA, van Hoeven N, Lu X, Dong L, Isakova-Sivak I, Chen LM, Voeten JT, Heldens JG, van den Bosch H, Cox NJ, Tumpey TM, Klimov AI, Rudenko L, Donis RO, Katz JM. Gustin KM, et al. Among authors: heldens jg. J Infect Dis. 2011 Nov 15;204(10):1491-9. doi: 10.1093/infdis/jir596. Epub 2011 Sep 28. J Infect Dis. 2011. PMID: 21957153
Characterization of reverse genetics-derived cold-adapted master donor virus A/Leningrad/134/17/57 (H2N2) and reassortants with H5N1 surface genes in a mouse model.
Isakova-Sivak I, Chen LM, Bourgeois M, Matsuoka Y, Voeten JT, Heldens JG, van den Bosch H, Klimov A, Rudenko L, Cox NJ, Donis RO. Isakova-Sivak I, et al. Among authors: heldens jg. Clin Vaccine Immunol. 2014 May;21(5):722-31. doi: 10.1128/CVI.00819-13. Epub 2014 Mar 19. Clin Vaccine Immunol. 2014. PMID: 24648485 Free PMC article.
A single immunization with CoVaccine HT-adjuvanted H5N1 influenza virus vaccine induces protective cellular and humoral immune responses in ferrets.
Bodewes R, Kreijtz JH, van Amerongen G, Geelhoed-Mieras MM, Verburgh RJ, Heldens JG, Bedwell J, van den Brand JM, Kuiken T, van Baalen CA, Fouchier RA, Osterhaus AD, Rimmelzwaan GF. Bodewes R, et al. Among authors: heldens jg. J Virol. 2010 Aug;84(16):7943-52. doi: 10.1128/JVI.00549-10. Epub 2010 Jun 2. J Virol. 2010. PMID: 20519384 Free PMC article.
Current challenges in implementing cell-derived influenza vaccines: implications for production and regulation, July 2007, NIBSC, Potters Bar, UK.
Minor PD, Engelhardt OG, Wood JM, Robertson JS, Blayer S, Colegate T, Fabry L, Heldens JG, Kino Y, Kistner O, Kompier R, Makizumi K, Medema J, Mimori S, Ryan D, Schwartz R, Smith JS, Sugawara K, Trusheim H, Tsai TF, Krause R. Minor PD, et al. Among authors: heldens jg. Vaccine. 2009 May 14;27(22):2907-13. doi: 10.1016/j.vaccine.2009.02.064. Epub 2009 Feb 27. Vaccine. 2009. PMID: 19366582 Review.
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