Kozma SC - Search Results

1

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage.

Stoica L, Zhu PJ, Huang W, Zhou H, Kozma SC, Costa-Mattioli M. Stoica L, et al. Among authors: kozma sc. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3791-6. doi: 10.1073/pnas.1014715108. Epub 2011 Feb 9. Proc Natl Acad Sci U S A. 2011. PMID: 21307309 Free PMC article.

2

Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production.

Alain T, Lun X, Martineau Y, Sean P, Pulendran B, Petroulakis E, Zemp FJ, Lemay CG, Roy D, Bell JC, Thomas G, Kozma SC, Forsyth PA, Costa-Mattioli M, Sonenberg N. Alain T, et al. Among authors: kozma sc. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1576-81. doi: 10.1073/pnas.0912344107. Epub 2010 Jan 4. Proc Natl Acad Sci U S A. 2010. PMID: 20080710 Free PMC article.

3

Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity.

Antion MD, Merhav M, Hoeffer CA, Reis G, Kozma SC, Thomas G, Schuman EM, Rosenblum K, Klann E. Antion MD, et al. Among authors: kozma sc. Learn Mem. 2008 Jan 3;15(1):29-38. doi: 10.1101/lm.661908. Print 2008 Jan. Learn Mem. 2008. PMID: 18174371 Free PMC article.

4

The Drosophila p70s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity.

Stewart MJ, Berry CO, Zilberman F, Thomas G, Kozma SC. Stewart MJ, et al. Among authors: kozma sc. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10791-6. doi: 10.1073/pnas.93.20.10791. Proc Natl Acad Sci U S A. 1996. PMID: 8855259 Free PMC article.

5

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

Jefferies HB, Reinhard C, Kozma SC, Thomas G. Jefferies HB, et al. Among authors: kozma sc. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4441-5. doi: 10.1073/pnas.91.10.4441. Proc Natl Acad Sci U S A. 1994. PMID: 8183928 Free PMC article.

6

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.

Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Egia A, Sasaki AT, Thomas G, Kozma SC, Papa A, Nardella C, Cantley LC, Baselga J, Pandolfi PP. Carracedo A, et al. Among authors: kozma sc. J Clin Invest. 2008 Sep;118(9):3065-74. doi: 10.1172/JCI34739. J Clin Invest. 2008. PMID: 18725988 Free PMC article.

7

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.

Dowling RJ, Topisirovic I, Alain T, Bidinosti M, Fonseca BD, Petroulakis E, Wang X, Larsson O, Selvaraj A, Liu Y, Kozma SC, Thomas G, Sonenberg N. Dowling RJ, et al. Among authors: kozma sc. Science. 2010 May 28;328(5982):1172-6. doi: 10.1126/science.1187532. Science. 2010. PMID: 20508131 Free PMC article.

8

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.

Kalender A, Selvaraj A, Kim SY, Gulati P, Brûlé S, Viollet B, Kemp BE, Bardeesy N, Dennis P, Schlager JJ, Marette A, Kozma SC, Thomas G. Kalender A, et al. Among authors: kozma sc. Cell Metab. 2010 May 5;11(5):390-401. doi: 10.1016/j.cmet.2010.03.014. Cell Metab. 2010. PMID: 20444419 Free PMC article.

9

Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth.

Zhu Y, Pires KM, Whitehead KJ, Olsen CD, Wayment B, Zhang YC, Bugger H, Ilkun O, Litwin SE, Thomas G, Kozma SC, Abel ED. Zhu Y, et al. Among authors: kozma sc. PLoS One. 2013;8(1):e54221. doi: 10.1371/journal.pone.0054221. Epub 2013 Jan 14. PLoS One. 2013. PMID: 23342106 Free PMC article.

10

EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice.

Arif A, Terenzi F, Potdar AA, Jia J, Sacks J, China A, Halawani D, Vasu K, Li X, Brown JM, Chen J, Kozma SC, Thomas G, Fox PL. Arif A, et al. Among authors: kozma sc. Nature. 2017 Feb 16;542(7641):357-361. doi: 10.1038/nature21380. Epub 2017 Feb 8. Nature. 2017. PMID: 28178239 Free PMC article.

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