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Tissue transglutaminase-mediated glutamine deamidation of beta-amyloid peptide increases peptide solubility, whereas enzymatic cross-linking and peptide fragmentation may serve as molecular triggers for rapid peptide aggregation.
Schmid AW, Condemi E, Tuchscherer G, Chiappe D, Mutter M, Vogel H, Moniatte M, Tsybin YO. Schmid AW, et al. Among authors: condemi e. J Biol Chem. 2011 Apr 8;286(14):12172-88. doi: 10.1074/jbc.M110.176149. Epub 2011 Feb 7. J Biol Chem. 2011. PMID: 21300794 Free PMC article.