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Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes.
Forbes JM, Söderlund J, Yap FY, Knip M, Andrikopoulos S, Ilonen J, Simell O, Veijola R, Sourris KC, Coughlan MT, Forsblom C, Slattery R, Grey ST, Wessman M, Yamamoto H, Bierhaus A, Cooper ME, Groop PH. Forbes JM, et al. Among authors: yap fy. Diabetologia. 2011 May;54(5):1032-42. doi: 10.1007/s00125-011-2058-z. Epub 2011 Feb 6. Diabetologia. 2011. PMID: 21298413
Advanced glycation end products are direct modulators of β-cell function.
Coughlan MT, Yap FY, Tong DC, Andrikopoulos S, Gasser A, Thallas-Bonke V, Webster DE, Miyazaki J, Kay TW, Slattery RM, Kaye DM, Drew BG, Kingwell BA, Fourlanos S, Groop PH, Harrison LC, Knip M, Forbes JM. Coughlan MT, et al. Among authors: yap fy. Diabetes. 2011 Oct;60(10):2523-32. doi: 10.2337/db10-1033. Epub 2011 Sep 12. Diabetes. 2011. PMID: 21911745 Free PMC article.
Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes.
Tesch G, Sourris KC, Summers SA, McCarthy D, Ward MS, Borg DJ, Gallo LA, Fotheringham AK, Pettit AR, Yap FY, Harcourt BE, Tan AL, Kausman JY, Nikolic-Paterson D, Kitching AR, Forbes JM. Tesch G, et al. Among authors: yap fy. Diabetologia. 2014 Sep;57(9):1977-85. doi: 10.1007/s00125-014-3291-z. Epub 2014 Jun 24. Diabetologia. 2014. PMID: 24957662
Increased liver AGEs induce hepatic injury mediated through an OST48 pathway.
Zhuang A, Yap FY, Bruce C, Leung C, Plan MR, Sullivan MA, Herath C, McCarthy D, Sourris KC, Kantharidis P, Coughlan MT, Febbraio MA, Hodson MP, Watt MJ, Angus P, Schulz BL, Forbes JM. Zhuang A, et al. Among authors: yap fy. Sci Rep. 2017 Sep 25;7(1):12292. doi: 10.1038/s41598-017-12548-4. Sci Rep. 2017. PMID: 28947796 Free PMC article.
The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition).
Zhuang A, Yap FYT, Borg DJ, McCarthy D, Fotheringham A, Leung S, Penfold SA, Sourris KC, Coughlan MT, Schulz BL, Forbes JM. Zhuang A, et al. Among authors: yap fyt. Endocrinol Diabetes Metab. 2021 Jun 22;4(3):e00278. doi: 10.1002/edm2.278. eCollection 2021 Jul. Endocrinol Diabetes Metab. 2021. PMID: 34277994 Free PMC article.
32 results