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Page 1
Discovery of S1P agonists with a dihydronaphthalene scaffold.
Kurata H, Kusumi K, Otsuki K, Suzuki R, Kurono M, Takada Y, Shioya H, Komiya T, Mizuno H, Ono T, Hagiya H, Minami M, Nakade S, Habashita H. Kurata H, et al. Among authors: nakade s. Bioorg Med Chem Lett. 2011 Jul 1;21(13):3885-9. doi: 10.1016/j.bmcl.2011.05.029. Epub 2011 May 15. Bioorg Med Chem Lett. 2011. PMID: 21641216
Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold.
Kurata H, Kusumi K, Otsuki K, Suzuki R, Kurono M, Tokuda N, Takada Y, Shioya H, Mizuno H, Komiya T, Ono T, Hagiya H, Minami M, Nakade S, Habashita H. Kurata H, et al. Among authors: nakade s. Bioorg Med Chem Lett. 2012 Jan 1;22(1):144-8. doi: 10.1016/j.bmcl.2011.11.048. Epub 2011 Nov 20. Bioorg Med Chem Lett. 2012. PMID: 22153936
Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of Autoimmune Diseases.
Kurata H, Kusumi K, Otsuki K, Suzuki R, Kurono M, Komiya T, Hagiya H, Mizuno H, Shioya H, Ono T, Takada Y, Maeda T, Matsunaga N, Kondo T, Tominaga S, Nunoya KI, Kiyoshi H, Komeno M, Nakade S, Habashita H. Kurata H, et al. Among authors: nakade s. J Med Chem. 2017 Dec 14;60(23):9508-9530. doi: 10.1021/acs.jmedchem.7b00785. Epub 2017 Nov 21. J Med Chem. 2017. PMID: 29120624
Efficacy and immunomodulatory actions of ONO-4641, a novel selective agonist for sphingosine 1-phosphate receptors 1 and 5, in preclinical models of multiple sclerosis.
Komiya T, Sato K, Shioya H, Inagaki Y, Hagiya H, Kozaki R, Imai M, Takada Y, Maeda T, Kurata H, Kurono M, Suzuki R, Otsuki K, Habashita H, Nakade S. Komiya T, et al. Among authors: nakade s. Clin Exp Immunol. 2013 Jan;171(1):54-62. doi: 10.1111/j.1365-2249.2012.04669.x. Clin Exp Immunol. 2013. PMID: 23199323 Free PMC article.
Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia.
Terakado M, Suzuki H, Hashimura K, Tanaka M, Ueda H, Hirai K, Asada M, Ikura M, Matsunaga N, Saga H, Shinozaki K, Karakawa N, Takada Y, Minami M, Egashira H, Sugiura Y, Yamada M, Nakade S, Takaoka Y. Terakado M, et al. Among authors: nakade s. ACS Med Chem Lett. 2017 Nov 20;8(12):1281-1286. doi: 10.1021/acsmedchemlett.7b00383. eCollection 2017 Dec 14. ACS Med Chem Lett. 2017. PMID: 29259748 Free PMC article.
Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1.
Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, Chun J, Stevens RC, Hanson MA. Chrencik JE, et al. Among authors: nakade s. Cell. 2015 Jun 18;161(7):1633-43. doi: 10.1016/j.cell.2015.06.002. Cell. 2015. PMID: 26091040 Free PMC article.
A novel highly potent autotaxin/ENPP2 inhibitor produces prolonged decreases in plasma lysophosphatidic acid formation in vivo and regulates urethral tension.
Saga H, Ohhata A, Hayashi A, Katoh M, Maeda T, Mizuno H, Takada Y, Komichi Y, Ota H, Matsumura N, Shibaya M, Sugiyama T, Nakade S, Kishikawa K. Saga H, et al. Among authors: nakade s. PLoS One. 2014 Apr 18;9(4):e93230. doi: 10.1371/journal.pone.0093230. eCollection 2014. PLoS One. 2014. PMID: 24747415 Free PMC article.
92 results