Kusumi K - Search Results

1

Structure-activity relationship studies of sphingosine-1-phosphate receptor agonists with N-cinnamyl-β-alanine moiety.

Kurata H, Otsuki K, Kusumi K, Kurono M, Terakado M, Seko T, Mizuno H, Ono T, Hagiya H, Minami M, Nakade S, Habashita H. Kurata H, et al. Among authors: kusumi k. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1390-3. doi: 10.1016/j.bmcl.2011.01.029. Epub 2011 Jan 11. Bioorg Med Chem Lett. 2011. PMID: 21295477

2

Discovery of S1P agonists with a dihydronaphthalene scaffold.

Kurata H, Kusumi K, Otsuki K, Suzuki R, Kurono M, Takada Y, Shioya H, Komiya T, Mizuno H, Ono T, Hagiya H, Minami M, Nakade S, Habashita H. Kurata H, et al. Among authors: kusumi k. Bioorg Med Chem Lett. 2011 Jul 1;21(13):3885-9. doi: 10.1016/j.bmcl.2011.05.029. Epub 2011 May 15. Bioorg Med Chem Lett. 2011. PMID: 21641216

3

Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold.

Kurata H, Kusumi K, Otsuki K, Suzuki R, Kurono M, Tokuda N, Takada Y, Shioya H, Mizuno H, Komiya T, Ono T, Hagiya H, Minami M, Nakade S, Habashita H. Kurata H, et al. Among authors: kusumi k. Bioorg Med Chem Lett. 2012 Jan 1;22(1):144-8. doi: 10.1016/j.bmcl.2011.11.048. Epub 2011 Nov 20. Bioorg Med Chem Lett. 2012. PMID: 22153936

4

Discovery of novel S1P2 antagonists. Part 1: discovery of 1,3-bis(aryloxy)benzene derivatives.

Kusumi K, Shinozaki K, Kanaji T, Kurata H, Naganawa A, Otsuki K, Matsushita T, Sekiguchi T, Kakuuchi A, Seko T. Kusumi K, et al. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1479-82. doi: 10.1016/j.bmcl.2015.02.029. Epub 2015 Feb 23. Bioorg Med Chem Lett. 2015. PMID: 25746814

5

Discovery of novel S1P2 antagonists. Part 2: Improving the profile of a series of 1,3-bis(aryloxy)benzene derivatives.

Kusumi K, Shinozaki K, Yamaura Y, Hashimoto A, Kurata H, Naganawa A, Ueda H, Otsuki K, Matsushita T, Sekiguchi T, Kakuuchi A, Seko T. Kusumi K, et al. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4387-92. doi: 10.1016/j.bmcl.2015.09.022. Epub 2015 Sep 8. Bioorg Med Chem Lett. 2015. PMID: 26384288

6

Discovery of novel S1P2 antagonists, part 3: Improving the oral bioavailability of a series of 1,3-bis(aryloxy)benzene derivatives.

Kusumi K, Shinozaki K, Yamaura Y, Hashimoto A, Kurata H, Naganawa A, Otsuki K, Matsushita T, Sekiguchi T, Kakuuchi A, Yamamoto H, Seko T. Kusumi K, et al. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1209-13. doi: 10.1016/j.bmcl.2016.01.031. Epub 2016 Jan 12. Bioorg Med Chem Lett. 2016. PMID: 26794040

7

Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P₁ and S1P₅ Selective Agonist for the Treatment of Autoimmune Diseases.

Kurata H, Kusumi K, Otsuki K, Suzuki R, Kurono M, Komiya T, Hagiya H, Mizuno H, Shioya H, Ono T, Takada Y, Maeda T, Matsunaga N, Kondo T, Tominaga S, Nunoya KI, Kiyoshi H, Komeno M, Nakade S, Habashita H. Kurata H, et al. Among authors: kusumi k. J Med Chem. 2017 Dec 14;60(23):9508-9530. doi: 10.1021/acs.jmedchem.7b00785. Epub 2017 Nov 21. J Med Chem. 2017. PMID: 29120624

8

6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists.

Saito T, Obitsu T, Kondo T, Matsui T, Nagao Y, Kusumi K, Matsumura N, Ueno S, Kishi A, Katsumata S, Kagamiishi Y, Nakai H, Toda M. Saito T, et al. Among authors: kusumi k. Bioorg Med Chem. 2011 Sep 15;19(18):5432-45. doi: 10.1016/j.bmc.2011.07.055. Epub 2011 Jul 31. Bioorg Med Chem. 2011. PMID: 21865047

9

Highly potent PDE4 inhibitors with therapeutic potential.

Ochiai H, Ohtani T, Ishida A, Kusumi K, Kato M, Kohno H, Odagaki Y, Kishikawa K, Yamamoto S, Takeda H, Obata T, Nakai H, Toda M. Ochiai H, et al. Among authors: kusumi k. Bioorg Med Chem. 2004 Sep 1;12(17):4645-65. doi: 10.1016/j.bmc.2004.06.032. Bioorg Med Chem. 2004. PMID: 15358291

10

Design, synthesis, and biological evaluation of new phosphodiesterase type 4 inhibitors.

Ochiai H, Odagaki Y, Ohtani T, Ishida A, Kusumi K, Kishikawa K, Yamamoto S, Takeda H, Obata T, Kobayashi K, Nakai H, Toda M. Ochiai H, et al. Among authors: kusumi k. Bioorg Med Chem. 2004 Oct 1;12(19):5063-78. doi: 10.1016/j.bmc.2004.07.040. Bioorg Med Chem. 2004. PMID: 15351390

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