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Minimal sequence variability of the region of HIV-1 integrase targeted by the Abbott RealTime HIV-1 viral load assay in clinical specimens with reduced susceptibility to raltegravir.
Young TP, Napolitano LA, Paquet AC, Parkin NT, Fransen S, Trinh R, Haddad M, Hackett J Jr, Cloherty GA. Young TP, et al. Among authors: fransen s. J Virol Methods. 2013 Nov;193(2):693-6. doi: 10.1016/j.jviromet.2013.07.028. Epub 2013 Jul 25. J Virol Methods. 2013. PMID: 23892128
Coreceptor tropism in human immunodeficiency virus type 1 subtype D: high prevalence of CXCR4 tropism and heterogeneous composition of viral populations.
Huang W, Eshleman SH, Toma J, Fransen S, Stawiski E, Paxinos EE, Whitcomb JM, Young AM, Donnell D, Mmiro F, Musoke P, Guay LA, Jackson JB, Parkin NT, Petropoulos CJ. Huang W, et al. Among authors: fransen s. J Virol. 2007 Aug;81(15):7885-93. doi: 10.1128/JVI.00218-07. Epub 2007 May 16. J Virol. 2007. PMID: 17507467 Free PMC article.
Suppression of dualtropic human immunodeficiency virus type 1 by the CXCR4 antagonist AMD3100 is associated with efficiency of CXCR4 use and baseline virus composition.
Fransen S, Bridger G, Whitcomb JM, Toma J, Stawiski E, Parkin N, Petropoulos CJ, Huang W. Fransen S, et al. Antimicrob Agents Chemother. 2008 Jul;52(7):2608-15. doi: 10.1128/AAC.01226-07. Epub 2008 Apr 28. Antimicrob Agents Chemother. 2008. PMID: 18443125 Free PMC article. Clinical Trial.
Characterization of human immunodeficiency virus type 1 populations containing CXCR4-using variants from recently infected individuals.
Huang W, Toma J, Stawiski E, Fransen S, Wrin T, Parkin N, Whitcomb JM, Coakley E, Hecht FM, Deeks SG, Gandhi RT, Eshleman SH, Petropoulos CJ. Huang W, et al. Among authors: fransen s. AIDS Res Hum Retroviruses. 2009 Aug;25(8):795-802. doi: 10.1089/aid.2008.0252. AIDS Res Hum Retroviruses. 2009. PMID: 19678765 Free PMC article.
Multiple genetic pathways involving amino acid position 143 of HIV-1 integrase are preferentially associated with specific secondary amino acid substitutions and confer resistance to raltegravir and cross-resistance to elvitegravir.
Huang W, Frantzell A, Fransen S, Petropoulos CJ. Huang W, et al. Among authors: fransen s. Antimicrob Agents Chemother. 2013 Sep;57(9):4105-13. doi: 10.1128/AAC.00204-13. Epub 2013 Jun 3. Antimicrob Agents Chemother. 2013. PMID: 23733474 Free PMC article.
121 results