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The decrease of glycolytic enzyme hexokinase 1 accelerates tumor malignancy via deregulating energy metabolism but sensitizes cancer cells to 2-deoxyglucose inhibition.
Tseng PL, Chen CW, Hu KH, Cheng HC, Lin YH, Tsai WH, Cheng TJ, Wu WH, Yeh CW, Lin CC, Tsai HJ, Chang HC, Chuang JH, Shan YS, Chang WT. Tseng PL, et al. Among authors: hu kh. Oncotarget. 2018 Apr 10;9(27):18949-18969. doi: 10.18632/oncotarget.24855. eCollection 2018 Apr 10. Oncotarget. 2018. PMID: 29721175 Free PMC article.
Comparing neoantigen cancer vaccines and immune checkpoint therapy unveils an effective vaccine and anti-TREM2 macrophage-targeting dual therapy.
Keshari S, Shavkunov AS, Miao Q, Saha A, Minowa T, Molgora M, Williams CD, Chaib M, Highsmith AM, Pineda JE, Alekseev S, Alspach E, Hu KH, Colonna M, Pauken KE, Chen K, Gubin MM. Keshari S, et al. Among authors: hu kh. Cell Rep. 2024 Nov 26;43(11):114875. doi: 10.1016/j.celrep.2024.114875. Epub 2024 Oct 23. Cell Rep. 2024. PMID: 39446585 Free PMC article.
Immediate myeloid depot for SARS-CoV-2 in the human lung.
Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Bernard O, Simoneau CR, Hysenaj L, Hu KH, Maishan M, Conrad C, Gbenedio OM, Samad B, Consortium TUC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Magnen M, et al. Among authors: hu kh. Sci Adv. 2024 Aug 2;10(31):eadm8836. doi: 10.1126/sciadv.adm8836. Epub 2024 Jul 31. Sci Adv. 2024. PMID: 39083602 Free PMC article.
Neoantigen Cancer Vaccines and Different Immune Checkpoint Therapies Each Utilize Both Converging and Distinct Mechanisms that in Combination Enable Synergistic Therapeutic Efficacy.
Keshari S, Shavkunov AS, Miao Q, Saha A, Williams CD, Highsmith AM, Pineda JE, Alspach E, Hu KH, Pauken KE, Chen K, Gubin MM. Keshari S, et al. Among authors: hu kh. bioRxiv [Preprint]. 2024 Jan 26:2023.12.20.570816. doi: 10.1101/2023.12.20.570816. bioRxiv. 2024. Update in: Cell Rep. 2024 Nov 26;43(11):114875. doi: 10.1016/j.celrep.2024.114875. PMID: 38187708 Free PMC article. Updated. Preprint.
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