Leake BF - Search Results

1

Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity.

Schwarz UI, Meyer zu Schwabedissen HE, Tirona RG, Suzuki A, Leake BF, Mokrab Y, Mizuguchi K, Ho RH, Kim RB. Schwarz UI, et al. Among authors: leake bf. Pharmacogenet Genomics. 2011 Mar;21(3):103-14. doi: 10.1097/FPC.0b013e328342f5b1. Pharmacogenet Genomics. 2011. PMID: 21278621 Free PMC article.

2

Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition.

Ho RH, Leake BF, Roberts RL, Lee W, Kim RB. Ho RH, et al. Among authors: leake bf. J Biol Chem. 2004 Feb 20;279(8):7213-22. doi: 10.1074/jbc.M305782200. Epub 2003 Dec 2. J Biol Chem. 2004. PMID: 14660639 Free article.

3

Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe.

Urquhart BL, Ware JA, Tirona RG, Ho RH, Leake BF, Schwarz UI, Zaher H, Palandra J, Gregor JC, Dresser GK, Kim RB. Urquhart BL, et al. Among authors: leake bf. Pharmacogenet Genomics. 2008 May;18(5):439-48. doi: 10.1097/FPC.0b013e3282f974dc. Pharmacogenet Genomics. 2008. PMID: 18408567 Free PMC article.

4

Human skeletal muscle drug transporters determine local exposure and toxicity of statins.

Knauer MJ, Urquhart BL, Meyer zu Schwabedissen HE, Schwarz UI, Lemke CJ, Leake BF, Kim RB, Tirona RG. Knauer MJ, et al. Among authors: leake bf. Circ Res. 2010 Feb 5;106(2):297-306. doi: 10.1161/CIRCRESAHA.109.203596. Epub 2009 Nov 25. Circ Res. 2010. PMID: 19940267

5

Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability.

Ho RH, Leake BF, Kilkenny DM, Meyer Zu Schwabedissen HE, Glaeser H, Kroetz DL, Kim RB. Ho RH, et al. Among authors: leake bf. Pharmacogenet Genomics. 2010 Jan;20(1):45-57. doi: 10.1097/FPC.0b013e3283349eb0. Pharmacogenet Genomics. 2010. PMID: 20010382 Free PMC article.

6

Interaction of three regiospecific amino acid residues is required for OATP1B1 gain of OATP1B3 substrate specificity.

DeGorter MK, Ho RH, Leake BF, Tirona RG, Kim RB. DeGorter MK, et al. Among authors: leake bf. Mol Pharm. 2012 Apr 2;9(4):986-95. doi: 10.1021/mp200629s. Epub 2012 Mar 6. Mol Pharm. 2012. PMID: 22352740 Free PMC article.

7

Contribution of hepatic organic anion-transporting polypeptides to docetaxel uptake and clearance.

Lee HH, Leake BF, Teft W, Tirona RG, Kim RB, Ho RH. Lee HH, et al. Among authors: leake bf. Mol Cancer Ther. 2015 Apr;14(4):994-1003. doi: 10.1158/1535-7163.MCT-14-0547. Epub 2015 Feb 18. Mol Cancer Ther. 2015. PMID: 25695959 Free PMC article.

8

Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.

Lee HH, Leake BF, Kim RB, Ho RH. Lee HH, et al. Among authors: leake bf. Mol Pharmacol. 2017 Jan;91(1):14-24. doi: 10.1124/mol.116.105544. Epub 2016 Oct 24. Mol Pharmacol. 2017. PMID: 27777271 Free PMC article.

9

Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation.

Tirona RG, Leake BF, Wolkoff AW, Kim RB. Tirona RG, et al. Among authors: leake bf. J Pharmacol Exp Ther. 2003 Jan;304(1):223-8. doi: 10.1124/jpet.102.043026. J Pharmacol Exp Ther. 2003. PMID: 12490595

10

Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine.

Dresser GK, Bailey DG, Leake BF, Schwarz UI, Dawson PA, Freeman DJ, Kim RB. Dresser GK, et al. Among authors: leake bf. Clin Pharmacol Ther. 2002 Jan;71(1):11-20. doi: 10.1067/mcp.2002.121152. Clin Pharmacol Ther. 2002. PMID: 11823753 Clinical Trial.

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