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4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors.
Liu KK, Bagrodia S, Bailey S, Cheng H, Chen H, Gao L, Greasley S, Hoffman JE, Hu Q, Johnson TO, Knighton D, Liu Z, Marx MA, Nambu MD, Ninkovic S, Pascual B, Rafidi K, Rodgers CM, Smith GL, Sun S, Wang H, Yang A, Yuan J, Zou A. Liu KK, et al. Among authors: knighton d. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6096-9. doi: 10.1016/j.bmcl.2010.08.045. Epub 2010 Aug 14. Bioorg Med Chem Lett. 2010. PMID: 20817449
Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design.
Cheng H, Li C, Bailey S, Baxi SM, Goulet L, Guo L, Hoffman J, Jiang Y, Johnson TO, Johnson TW, Knighton DR, Li J, Liu KK, Liu Z, Marx MA, Walls M, Wells PA, Yin MJ, Zhu J, Zientek M. Cheng H, et al. Among authors: knighton dr. ACS Med Chem Lett. 2012 Nov 7;4(1):91-7. doi: 10.1021/ml300309h. eCollection 2013 Jan 10. ACS Med Chem Lett. 2012. PMID: 24900568 Free PMC article.
A template for the protein kinase family.
Taylor SS, Knighton DR, Zheng J, Sowadski JM, Gibbs CS, Zoller MJ. Taylor SS, et al. Among authors: knighton dr. Trends Biochem Sci. 1993 Mar;18(3):84-9. doi: 10.1016/0968-0004(93)80001-r. Trends Biochem Sci. 1993. PMID: 8480367 Review.
cAMP-dependent protein kinase and the protein kinase family.
Taylor SS, Knighton DR, Zheng J, Ten Eyck LF, Sowadski JM. Taylor SS, et al. Among authors: knighton dr. Faraday Discuss. 1992;(93):143-52. doi: 10.1039/fd9929300143. Faraday Discuss. 1992. PMID: 1290929 Review.
Structure-based design of novel, urea-containing FKBP12 inhibitors.
Dragovich PS, Barker JE, French J, Imbacuan M, Kalish VJ, Kissinger CR, Knighton DR, Lewis CT, Moomaw EW, Parge HE, Pelletier LA, Prins TJ, Showalter RE, Tatlock JH, Tucker KD, Villafranca JE. Dragovich PS, et al. Among authors: knighton dr. J Med Chem. 1996 Apr 26;39(9):1872-84. doi: 10.1021/jm950798a. J Med Chem. 1996. PMID: 8627611
Structural framework for the protein kinase family.
Taylor SS, Knighton DR, Zheng J, Ten Eyck LF, Sowadski JM. Taylor SS, et al. Among authors: knighton dr. Annu Rev Cell Biol. 1992;8:429-62. doi: 10.1146/annurev.cb.08.110192.002241. Annu Rev Cell Biol. 1992. PMID: 1335745 Review.
102 results