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Page 1
Genetic determinants of white matter hyperintensities and amyloid angiopathy in familial Alzheimer's disease.
Ryan NS, Biessels GJ, Kim L, Nicholas JM, Barber PA, Walsh P, Gami P, Morris HR, Bastos-Leite AJ, Schott JM, Beck J, Mead S, Chavez-Gutierrez L, de Strooper B, Rossor MN, Revesz T, Lashley T, Fox NC. Ryan NS, et al. Among authors: de strooper b. Neurobiol Aging. 2015 Dec;36(12):3140-3151. doi: 10.1016/j.neurobiolaging.2015.08.026. Epub 2015 Sep 4. Neurobiol Aging. 2015. PMID: 26410308
Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.
Szaruga M, Veugelen S, Benurwar M, Lismont S, Sepulveda-Falla D, Lleo A, Ryan NS, Lashley T, Fox NC, Murayama S, Gijsen H, De Strooper B, Chávez-Gutiérrez L. Szaruga M, et al. Among authors: de strooper b. J Exp Med. 2015 Nov 16;212(12):2003-13. doi: 10.1084/jem.20150892. Epub 2015 Oct 19. J Exp Med. 2015. PMID: 26481686 Free PMC article.
Alzheimer's disease.
Scheltens P, Blennow K, Breteler MM, de Strooper B, Frisoni GB, Salloway S, Van der Flier WM. Scheltens P, et al. Among authors: de strooper b. Lancet. 2016 Jul 30;388(10043):505-17. doi: 10.1016/S0140-6736(15)01124-1. Epub 2016 Feb 24. Lancet. 2016. PMID: 26921134 Free article. Review.
Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.
Ryan NS, Nicholas JM, Weston PSJ, Liang Y, Lashley T, Guerreiro R, Adamson G, Kenny J, Beck J, Chavez-Gutierrez L, de Strooper B, Revesz T, Holton J, Mead S, Rossor MN, Fox NC. Ryan NS, et al. Among authors: de strooper b. Lancet Neurol. 2016 Dec;15(13):1326-1335. doi: 10.1016/S1474-4422(16)30193-4. Epub 2016 Oct 21. Lancet Neurol. 2016. PMID: 27777022 Free article.
The case for low-level BACE1 inhibition for the prevention of Alzheimer disease.
McDade E, Voytyuk I, Aisen P, Bateman RJ, Carrillo MC, De Strooper B, Haass C, Reiman EM, Sperling R, Tariot PN, Yan R, Masters CL, Vassar R, Lichtenthaler SF. McDade E, et al. Among authors: de strooper b. Nat Rev Neurol. 2021 Nov;17(11):703-714. doi: 10.1038/s41582-021-00545-1. Epub 2021 Sep 21. Nat Rev Neurol. 2021. PMID: 34548654 Review.
Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.
Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, De Strooper B, Chávez-Gutiérrez L. Szaruga M, et al. Among authors: de strooper b, de vos t. Cell. 2017 Jul 27;170(3):443-456.e14. doi: 10.1016/j.cell.2017.07.004. Cell. 2017. PMID: 28753424 Free article.
EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer's disease.
Poppe L, Rué L, Timmers M, Lenaerts A, Storm A, Callaerts-Vegh Z, Courtand G, de Boer A, Smolders S, Van Damme P, Van Den Bosch L, D'Hooge R, De Strooper B, Robberecht W, Lemmens R. Poppe L, et al. Among authors: de strooper b, de boer a. Alzheimers Res Ther. 2019 Dec 12;11(1):102. doi: 10.1186/s13195-019-0554-4. Alzheimers Res Ther. 2019. PMID: 31831046 Free PMC article.
Alzheimer's-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions.
Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, De Strooper B, Chávez-Gutiérrez L. Szaruga M, et al. Among authors: de strooper b, de vos t. Cell. 2021 Apr 15;184(8):2257-2258. doi: 10.1016/j.cell.2021.03.058. Cell. 2021. PMID: 33861967 Free article. No abstract available.
410 results