Shen B - Search Results

1

Comparative analysis of the biosynthetic gene clusters and pathways for three structurally related antitumor antibiotics: bleomycin, tallysomycin, and zorbamycin.

Galm U, Wendt-Pienkowski E, Wang L, Huang SX, Unsin C, Tao M, Coughlin JM, Shen B. Galm U, et al. Among authors: shen b. J Nat Prod. 2011 Mar 25;74(3):526-36. doi: 10.1021/np1008152. Epub 2011 Jan 6. J Nat Prod. 2011. PMID: 21210656 Free PMC article. Review.

2

Cloning and characterization of the bleomycin biosynthetic gene cluster from Streptomyces verticillus ATCC15003.

Shen B, Du L, Sanchez C, Edwards DJ, Chen M, Murrell JM. Shen B, et al. J Nat Prod. 2002 Mar;65(3):422-31. doi: 10.1021/np010550q. J Nat Prod. 2002. PMID: 11908996 Review.

3

Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140.

Cheng YQ, Tang GL, Shen B. Cheng YQ, et al. Among authors: shen b. J Bacteriol. 2002 Dec;184(24):7013-24. doi: 10.1128/JB.184.24.7013-7024.2002. J Bacteriol. 2002. PMID: 12446651 Free PMC article.

4

BlmIII and BlmIV nonribosomal peptide synthetase-catalyzed biosynthesis of the bleomycin bithiazole moiety involving both in cis and in trans aminoacylation.

Du L, Chen M, Zhang Y, Shen B. Du L, et al. Among authors: shen b. Biochemistry. 2003 Aug 19;42(32):9731-40. doi: 10.1021/bi034817r. Biochemistry. 2003. PMID: 12911315

5

Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model.

Liu W, Ahlert J, Gao Q, Wendt-Pienkowski E, Shen B, Thorson JS. Liu W, et al. Among authors: shen b. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):11959-63. doi: 10.1073/pnas.2034291100. Epub 2003 Oct 3. Proc Natl Acad Sci U S A. 2003. PMID: 14528002 Free PMC article.

6

Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase.

Tang GL, Cheng YQ, Shen B. Tang GL, et al. Among authors: shen b. Chem Biol. 2004 Jan;11(1):33-45. doi: 10.1016/j.chembiol.2003.12.014. Chem Biol. 2004. PMID: 15112993 Free article.

7

Antitumor antibiotics: bleomycin, enediynes, and mitomycin.

Galm U, Hager MH, Van Lanen SG, Ju J, Thorson JS, Shen B. Galm U, et al. Among authors: shen b. Chem Rev. 2005 Feb;105(2):739-58. doi: 10.1021/cr030117g. Chem Rev. 2005. PMID: 15700963 No abstract available.

8

Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus.

Wendt-Pienkowski E, Huang Y, Zhang J, Li B, Jiang H, Kwon H, Hutchinson CR, Shen B. Wendt-Pienkowski E, et al. Among authors: shen b. J Am Chem Soc. 2005 Nov 30;127(47):16442-52. doi: 10.1021/ja054376u. J Am Chem Soc. 2005. PMID: 16305230

9

Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140.

Tang GL, Cheng YQ, Shen B. Tang GL, et al. Among authors: shen b. J Nat Prod. 2006 Mar;69(3):387-93. doi: 10.1021/np050467t. J Nat Prod. 2006. PMID: 16562841 Free PMC article.

10

A dedicated phosphopantetheinyl transferase for the fredericamycin polyketide synthase from Streptomyces griseus.

Huang Y, Wendt-Pienkowski E, Shen B. Huang Y, et al. Among authors: shen b. J Biol Chem. 2006 Oct 6;281(40):29660-8. doi: 10.1074/jbc.M604895200. Epub 2006 Aug 8. J Biol Chem. 2006. PMID: 16895912 Free article.

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