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The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants.
Glas J, Seiderer J, Tillack C, Pfennig S, Beigel F, Jürgens M, Olszak T, Laubender RP, Weidinger M, Müller-Myhsok B, Göke B, Ochsenkühn T, Lohse P, Diegelmann J, Czamara D, Brand S. Glas J, et al. Among authors: seiderer j. PLoS One. 2010 Dec 30;5(12):e14466. doi: 10.1371/journal.pone.0014466. PLoS One. 2010. PMID: 21209938 Free PMC article.
Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease.
Török HP, Glas J, Tonenchi L, Lohse P, Müller-Myhsok B, Limbersky O, Neugebauer C, Schnitzler F, Seiderer J, Tillack C, Brand S, Brünnler G, Jagiello P, Epplen JT, Griga T, Klein W, Schiemann U, Folwaczny M, Ochsenkühn T, Folwaczny C. Török HP, et al. Among authors: seiderer j. Gut. 2005 Oct;54(10):1421-7. doi: 10.1136/gut.2005.066340. Epub 2005 Jun 14. Gut. 2005. PMID: 15955786 Free PMC article.
The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease.
Brand S, Staudinger T, Schnitzler F, Pfennig S, Hofbauer K, Dambacher J, Seiderer J, Tillack C, Konrad A, Crispin A, Göke B, Lohse P, Ochsenkühn T. Brand S, et al. Among authors: seiderer j. Inflamm Bowel Dis. 2005 Jul;11(7):645-52. doi: 10.1097/01.mib.0000168372.94907.d2. Inflamm Bowel Dis. 2005. PMID: 15973118
Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn's disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis.
Seiderer J, Schnitzler F, Brand S, Staudinger T, Pfennig S, Herrmann K, Hofbauer K, Dambacher J, Tillack C, Sackmann M, Göke B, Lohse P, Ochsenkühn T. Seiderer J, et al. Scand J Gastroenterol. 2006 Dec;41(12):1421-32. doi: 10.1080/00365520600703900. Scand J Gastroenterol. 2006. PMID: 17101573
rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.
Glas J, Seiderer J, Wetzke M, Konrad A, Török HP, Schmechel S, Tonenchi L, Grassl C, Dambacher J, Pfennig S, Maier K, Griga T, Klein W, Epplen JT, Schiemann U, Folwaczny C, Lohse P, Göke B, Ochsenkühn T, Müller-Myhsok B, Folwaczny M, Mussack T, Brand S. Glas J, et al. Among authors: seiderer j. PLoS One. 2007 Sep 5;2(9):e819. doi: 10.1371/journal.pone.0000819. PLoS One. 2007. PMID: 17786191 Free PMC article.
Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD.
Seiderer J, Elben I, Diegelmann J, Glas J, Stallhofer J, Tillack C, Pfennig S, Jürgens M, Schmechel S, Konrad A, Göke B, Ochsenkühn T, Müller-Myhsok B, Lohse P, Brand S. Seiderer J, et al. Inflamm Bowel Dis. 2008 Apr;14(4):437-45. doi: 10.1002/ibd.20339. Inflamm Bowel Dis. 2008. PMID: 18088064
The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population.
Glas J, Konrad A, Schmechel S, Dambacher J, Seiderer J, Schroff F, Wetzke M, Roeske D, Török HP, Tonenchi L, Pfennig S, Haller D, Griga T, Klein W, Epplen JT, Folwaczny C, Lohse P, Göke B, Ochsenkühn T, Mussack T, Folwaczny M, Müller-Myhsok B, Brand S. Glas J, et al. Among authors: seiderer j. Am J Gastroenterol. 2008 Mar;103(3):682-91. doi: 10.1111/j.1572-0241.2007.01694.x. Epub 2007 Dec 20. Am J Gastroenterol. 2008. PMID: 18162085
57 results