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Page 1
Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.
Tebbenkamp AT, Green C, Xu G, Denovan-Wright EM, Rising AC, Fromholt SE, Brown HH, Swing D, Mandel RJ, Tessarollo L, Borchelt DR. Tebbenkamp AT, et al. Among authors: rising ac. Hum Mol Genet. 2011 Jul 15;20(14):2770-82. doi: 10.1093/hmg/ddr176. Epub 2011 Apr 22. Hum Mol Genet. 2011. PMID: 21515588 Free PMC article.
AAV9: a potential blood-brain barrier buster.
Manfredsson FP, Rising AC, Mandel RJ. Manfredsson FP, et al. Among authors: rising ac. Mol Ther. 2009 Mar;17(3):403-5. doi: 10.1038/mt.2009.15. Mol Ther. 2009. PMID: 19247366 Free PMC article. No abstract available.
Clinical-grade stem cell-derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs.
Sharma R, Khristov V, Rising A, Jha BS, Dejene R, Hotaling N, Li Y, Stoddard J, Stankewicz C, Wan Q, Zhang C, Campos MM, Miyagishima KJ, McGaughey D, Villasmil R, Mattapallil M, Stanzel B, Qian H, Wong W, Chase L, Charles S, McGill T, Miller S, Maminishkis A, Amaral J, Bharti K. Sharma R, et al. Sci Transl Med. 2019 Jan 16;11(475):eaat5580. doi: 10.1126/scitranslmed.aat5580. Sci Transl Med. 2019. PMID: 30651323 Free PMC article.
Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model.
Sharma R, George A, Nimmagadda M, Ortolan D, Karla BS, Qureshy Z, Bose D, Dejene R, Liang G, Wan Q, Chang J, Jha BS, Memon O, Miyagishima KJ, Rising A, Lal M, Hanson E, King R, Campos MM, Ferrer M, Amaral J, McGaughey D, Bharti K. Sharma R, et al. Nat Commun. 2021 Dec 15;12(1):7293. doi: 10.1038/s41467-021-27488-x. Nat Commun. 2021. PMID: 34911940 Free PMC article.
Validation of iPS Cell-Derived RPE Tissue in Animal Models.
Khristov V, Maminishkis A, Amaral J, Rising A, Bharti K, Miller S. Khristov V, et al. Adv Exp Med Biol. 2018;1074:633-640. doi: 10.1007/978-3-319-75402-4_77. Adv Exp Med Biol. 2018. PMID: 29721997 Free PMC article.