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Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Deelen J, Beekman M, Uh HW, Helmer Q, Kuningas M, Christiansen L, Kremer D, van der Breggen R, Suchiman HE, Lakenberg N, van den Akker EB, Passtoors WM, Tiemeier H, van Heemst D, de Craen AJ, Rivadeneira F, de Geus EJ, Perola M, van der Ouderaa FJ, Gunn DA, Boomsma DI, Uitterlinden AG, Christensen K, van Duijn CM, Heijmans BT, Houwing-Duistermaat JJ, Westendorp RG, Slagboom PE. Deelen J, et al. Among authors: de craen aj, de geus ej. Aging Cell. 2011 Aug;10(4):686-98. doi: 10.1111/j.1474-9726.2011.00705.x. Epub 2011 May 6. Aging Cell. 2011. PMID: 21418511 Free PMC article.
Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study.
Westendorp RG, van Heemst D, Rozing MP, Frölich M, Mooijaart SP, Blauw GJ, Beekman M, Heijmans BT, de Craen AJ, Slagboom PE; Leiden Longevity Study Group. Westendorp RG, et al. Among authors: de craen aj. J Am Geriatr Soc. 2009 Sep;57(9):1634-7. doi: 10.1111/j.1532-5415.2009.02381.x. Epub 2009 Jul 17. J Am Geriatr Soc. 2009. PMID: 19682117
Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study.
Rozing MP, Westendorp RG, de Craen AJ, Frölich M, Heijmans BT, Beekman M, Wijsman C, Mooijaart SP, Blauw GJ, Slagboom PE, van Heemst D; Leiden Longevity Study (LLS) Group. Rozing MP, et al. Among authors: de craen aj. J Gerontol A Biol Sci Med Sci. 2010 Apr;65(4):365-8. doi: 10.1093/gerona/glp200. Epub 2009 Dec 16. J Gerontol A Biol Sci Med Sci. 2010. PMID: 20018826
Human insulin/IGF-1 and familial longevity at middle age.
Rozing MP, Westendorp RG, Frölich M, de Craen AJ, Beekman M, Heijmans BT, Mooijaart SP, Blauw GJ, Slagboom PE, van Heemst D; Leiden Longevity Study (LLS) Group. Rozing MP, et al. Among authors: de craen aj. Aging (Albany NY). 2009 Jul 24;1(8):714-22. doi: 10.18632/aging.100071. Aging (Albany NY). 2009. PMID: 20157552 Free PMC article.
Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study.
Rozing MP, Westendorp RG, de Craen AJ, Frölich M, de Goeij MC, Heijmans BT, Beekman M, Wijsman CA, Mooijaart SP, Blauw GJ, Slagboom PE, van Heemst D; Leiden Longevity Study Group. Rozing MP, et al. Among authors: de craen aj, de goeij mc. J Am Geriatr Soc. 2010 Mar;58(3):564-9. doi: 10.1111/j.1532-5415.2010.02725.x. J Am Geriatr Soc. 2010. PMID: 20398121
Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity.
Beekman M, Nederstigt C, Suchiman HE, Kremer D, van der Breggen R, Lakenberg N, Alemayehu WG, de Craen AJ, Westendorp RG, Boomsma DI, de Geus EJ, Houwing-Duistermaat JJ, Heijmans BT, Slagboom PE. Beekman M, et al. Among authors: de craen aj, de geus ej. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18046-9. doi: 10.1073/pnas.1003540107. Epub 2010 Oct 4. Proc Natl Acad Sci U S A. 2010. PMID: 20921414 Free PMC article.
Homocysteine and familial longevity: the Leiden Longevity Study.
Wijsman CA, van Heemst D, Rozing MP, Slagboom PE, Beekman M, de Craen AJ, Maier AB, Westendorp RG, Blom HJ, Mooijaart SP. Wijsman CA, et al. Among authors: de craen aj. PLoS One. 2011 Mar 8;6(3):e17543. doi: 10.1371/journal.pone.0017543. PLoS One. 2011. PMID: 21408159 Free PMC article.
464 results