Lee JW - Search Results

1

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase.

Hirota T, Lee JW, Lewis WG, Zhang EE, Breton G, Liu X, Garcia M, Peters EC, Etchegaray JP, Traver D, Schultz PG, Kay SA. Hirota T, et al. Among authors: lee jw. PLoS Biol. 2010 Dec 14;8(12):e1000559. doi: 10.1371/journal.pbio.1000559. PLoS Biol. 2010. PMID: 21179498 Free PMC article.

2

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta.

Hirota T, Lewis WG, Liu AC, Lee JW, Schultz PG, Kay SA. Hirota T, et al. Among authors: lee jw. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20746-51. doi: 10.1073/pnas.0811410106. Epub 2008 Dec 22. Proc Natl Acad Sci U S A. 2008. PMID: 19104043 Free PMC article.

3

A small molecule modulates circadian rhythms through phosphorylation of the period protein.

Lee JW, Hirota T, Peters EC, Garcia M, Gonzalez R, Cho CY, Wu X, Schultz PG, Kay SA. Lee JW, et al. Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10608-11. doi: 10.1002/anie.201103915. Epub 2011 Sep 26. Angew Chem Int Ed Engl. 2011. PMID: 21954091 Free PMC article.

4

Identification of small molecule activators of cryptochrome.

Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T, Welsh DK, Brenner DA, Doyle FJ 3rd, Schultz PG, Kay SA. Hirota T, et al. Among authors: lee jw. Science. 2012 Aug 31;337(6098):1094-7. doi: 10.1126/science.1223710. Epub 2012 Jul 12. Science. 2012. PMID: 22798407 Free PMC article.

5

Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock.

Lee JW, Hirota T, Kumar A, Kim NJ, Irle S, Kay SA. Lee JW, et al. ChemMedChem. 2015 Sep;10(9):1489-97. doi: 10.1002/cmdc.201500260. Epub 2015 Jul 14. ChemMedChem. 2015. PMID: 26174033 Free PMC article.

6

Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ.

Lee JW, Hirota T, Ono D, Honma S, Honma KI, Park K, Kay SA. Lee JW, et al. J Med Chem. 2019 Feb 28;62(4):1989-1998. doi: 10.1021/acs.jmedchem.8b01541. Epub 2019 Feb 15. J Med Chem. 2019. PMID: 30707835 Free PMC article.

7

A method to site-specifically introduce methyllysine into proteins in E. coli.

Ai HW, Lee JW, Schultz PG. Ai HW, et al. Among authors: lee jw. Chem Commun (Camb). 2010 Aug 14;46(30):5506-8. doi: 10.1039/c0cc00108b. Epub 2010 Jun 22. Chem Commun (Camb). 2010. PMID: 20571694 Free PMC article.

8

Stepwise chemically induced cardiomyocyte specification of human embryonic stem cells.

Gonzalez R, Lee JW, Schultz PG. Gonzalez R, et al. Among authors: lee jw. Angew Chem Int Ed Engl. 2011 Nov 18;50(47):11181-5. doi: 10.1002/anie.201103909. Angew Chem Int Ed Engl. 2011. PMID: 22191091 No abstract available.

9

Dorsomorphin promotes human embryonic stem cell self-renewal.

Gonzalez R, Lee JW, Snyder EY, Schultz PG. Gonzalez R, et al. Among authors: lee jw. Angew Chem Int Ed Engl. 2011 Apr 4;50(15):3439-41. doi: 10.1002/anie.201005659. Epub 2011 Mar 7. Angew Chem Int Ed Engl. 2011. PMID: 21384475 No abstract available.

10

A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer.

Lucki NC, Villa GR, Vergani N, Bollong MJ, Beyer BA, Lee JW, Anglin JL, Spangenberg SH, Chin EN, Sharma A, Johnson K, Sander PN, Gordon P, Skirboll SL, Wurdak H, Schultz PG, Mischel PS, Lairson LL. Lucki NC, et al. Among authors: lee jw. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6435-6440. doi: 10.1073/pnas.1816626116. Epub 2019 Mar 7. Proc Natl Acad Sci U S A. 2019. PMID: 30846550 Free PMC article.

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