Hirota T - Search Results

1

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase.

Hirota T, Lee JW, Lewis WG, Zhang EE, Breton G, Liu X, Garcia M, Peters EC, Etchegaray JP, Traver D, Schultz PG, Kay SA. Hirota T, et al. PLoS Biol. 2010 Dec 14;8(12):e1000559. doi: 10.1371/journal.pbio.1000559. PLoS Biol. 2010. PMID: 21179498 Free PMC article.

2

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta.

Hirota T, Lewis WG, Liu AC, Lee JW, Schultz PG, Kay SA. Hirota T, et al. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20746-51. doi: 10.1073/pnas.0811410106. Epub 2008 Dec 22. Proc Natl Acad Sci U S A. 2008. PMID: 19104043 Free PMC article.

3

A genome-wide RNAi screen for modifiers of the circadian clock in human cells.

Zhang EE, Liu AC, Hirota T, Miraglia LJ, Welch G, Pongsawakul PY, Liu X, Atwood A, Huss JW 3rd, Janes J, Su AI, Hogenesch JB, Kay SA. Zhang EE, et al. Among authors: hirota t. Cell. 2009 Oct 2;139(1):199-210. doi: 10.1016/j.cell.2009.08.031. Epub 2009 Sep 17. Cell. 2009. PMID: 19765810 Free PMC article.

4

High-throughput screening and chemical biology: new approaches for understanding circadian clock mechanisms.

Hirota T, Kay SA. Hirota T, et al. Chem Biol. 2009 Sep 25;16(9):921-7. doi: 10.1016/j.chembiol.2009.09.002. Chem Biol. 2009. PMID: 19778719 Free PMC article.

5

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis.

Zhang EE, Liu Y, Dentin R, Pongsawakul PY, Liu AC, Hirota T, Nusinow DA, Sun X, Landais S, Kodama Y, Brenner DA, Montminy M, Kay SA. Zhang EE, et al. Among authors: hirota t. Nat Med. 2010 Oct;16(10):1152-6. doi: 10.1038/nm.2214. Epub 2010 Sep 19. Nat Med. 2010. PMID: 20852621 Free PMC article.

6

A small molecule modulates circadian rhythms through phosphorylation of the period protein.

Lee JW, Hirota T, Peters EC, Garcia M, Gonzalez R, Cho CY, Wu X, Schultz PG, Kay SA. Lee JW, et al. Among authors: hirota t. Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10608-11. doi: 10.1002/anie.201103915. Epub 2011 Sep 26. Angew Chem Int Ed Engl. 2011. PMID: 21954091 Free PMC article.

7

Identification of small molecule activators of cryptochrome.

Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T, Welsh DK, Brenner DA, Doyle FJ 3rd, Schultz PG, Kay SA. Hirota T, et al. Science. 2012 Aug 31;337(6098):1094-7. doi: 10.1126/science.1223710. Epub 2012 Jul 12. Science. 2012. PMID: 22798407 Free PMC article.

8

Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock.

St John PC, Hirota T, Kay SA, Doyle FJ 3rd. St John PC, et al. Among authors: hirota t. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):2040-5. doi: 10.1073/pnas.1323618111. Epub 2014 Jan 21. Proc Natl Acad Sci U S A. 2014. PMID: 24449901 Free PMC article.

9

Identification of small-molecule modulators of the circadian clock.

Hirota T, Kay SA. Hirota T, et al. Methods Enzymol. 2015;551:267-82. doi: 10.1016/bs.mie.2014.10.015. Epub 2014 Dec 12. Methods Enzymol. 2015. PMID: 25662461

10

Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock.

Lee JW, Hirota T, Kumar A, Kim NJ, Irle S, Kay SA. Lee JW, et al. Among authors: hirota t. ChemMedChem. 2015 Sep;10(9):1489-97. doi: 10.1002/cmdc.201500260. Epub 2015 Jul 14. ChemMedChem. 2015. PMID: 26174033 Free PMC article.

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