Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
Kaida D, Motoyoshi H, Tashiro E, Nojima T, Hagiwara M, Ishigami K, Watanabe H, Kitahara T, Yoshida T, Nakajima H, Tani T, Horinouchi S, Yoshida M.
Kaida D, et al. Among authors: yoshida t, yoshida m.
Nat Chem Biol. 2007 Sep;3(9):576-83. doi: 10.1038/nchembio.2007.18. Epub 2007 Jul 22.
Nat Chem Biol. 2007.
PMID: 17643111