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Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling.
Levy D, Kuo AJ, Chang Y, Schaefer U, Kitson C, Cheung P, Espejo A, Zee BM, Liu CL, Tangsombatvisit S, Tennen RI, Kuo AY, Tanjing S, Cheung R, Chua KF, Utz PJ, Shi X, Prinjha RK, Lee K, Garcia BA, Bedford MT, Tarakhovsky A, Cheng X, Gozani O. Levy D, et al. Among authors: chua kf. Nat Immunol. 2011 Jan;12(1):29-36. doi: 10.1038/ni.1968. Epub 2010 Dec 5. Nat Immunol. 2011. PMID: 21131967 Free PMC article.
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.
Shi X, Hong T, Walter KL, Ewalt M, Michishita E, Hung T, Carney D, Peña P, Lan F, Kaadige MR, Lacoste N, Cayrou C, Davrazou F, Saha A, Cairns BR, Ayer DE, Kutateladze TG, Shi Y, Côté J, Chua KF, Gozani O. Shi X, et al. Among authors: chua kf. Nature. 2006 Jul 6;442(7098):96-9. doi: 10.1038/nature04835. Epub 2006 May 21. Nature. 2006. PMID: 16728974 Free PMC article.
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.
Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, Cheung P, Kusumoto R, Kawahara TL, Barrett JC, Chang HY, Bohr VA, Ried T, Gozani O, Chua KF. Michishita E, et al. Among authors: chua kf. Nature. 2008 Mar 27;452(7186):492-6. doi: 10.1038/nature06736. Epub 2008 Mar 12. Nature. 2008. PMID: 18337721 Free PMC article.
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation.
Barber MF, Michishita-Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, Tennen RI, Paredes S, Young NL, Chen K, Struhl K, Garcia BA, Gozani O, Li W, Chua KF. Barber MF, et al. Among authors: chua kf. Nature. 2012 Jul 5;487(7405):114-8. doi: 10.1038/nature11043. Nature. 2012. PMID: 22722849 Free PMC article.
Elevated NSD3 histone methylation activity drives squamous cell lung cancer.
Yuan G, Flores NM, Hausmann S, Lofgren SM, Kharchenko V, Angulo-Ibanez M, Sengupta D, Lu X, Czaban I, Azhibek D, Vicent S, Fischle W, Jaremko M, Fang B, Wistuba II, Chua KF, Roth JA, Minna JD, Shao NY, Jaremko Ł, Mazur PK, Gozani O. Yuan G, et al. Among authors: chua kf. Nature. 2021 Feb;590(7846):504-508. doi: 10.1038/s41586-020-03170-y. Epub 2021 Feb 3. Nature. 2021. PMID: 33536620 Free PMC article.
Chromatin regulation and genome maintenance by mammalian SIRT6.
Tennen RI, Chua KF. Tennen RI, et al. Among authors: chua kf. Trends Biochem Sci. 2011 Jan;36(1):39-46. doi: 10.1016/j.tibs.2010.07.009. Epub 2010 Aug 21. Trends Biochem Sci. 2011. PMID: 20729089 Free PMC article. Review.
43 results