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A novel series of potent and selective EP(4) receptor ligands: facile modulation of agonism and antagonism.
Bioorg Med Chem Lett. 2011 Jan 1;21(1):484-7. doi: 10.1016/j.bmcl.2010.10.106. Epub 2010 Oct 28.
Bioorg Med Chem Lett. 2011.
PMID: 21126875
Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain.
Colucci J, Boyd M, Berthelette C, Chiasson JF, Wang Z, Ducharme Y, Friesen R, Wrona M, Levesque JF, Denis D, Mathieu MC, Stocco R, Therien AG, Clarke P, Rowland S, Xu D, Han Y.
Colucci J, et al. Among authors: chiasson jf.
Bioorg Med Chem Lett. 2010 Jun 15;20(12):3760-3. doi: 10.1016/j.bmcl.2010.04.065. Epub 2010 Apr 18.
Bioorg Med Chem Lett. 2010.
PMID: 20471829
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Trisubstituted ureas as potent and selective mPGES-1 inhibitors.
Chiasson JF, Boulet L, Brideau C, Chau A, Claveau D, Côté B, Ethier D, Giroux A, Guay J, Guiral S, Mancini J, Massé F, Méthot N, Riendeau D, Roy P, Rubin J, Xu D, Yu H, Ducharme Y, Friesen RW.
Chiasson JF, et al.
Bioorg Med Chem Lett. 2011 Mar 1;21(5):1488-92. doi: 10.1016/j.bmcl.2011.01.006. Epub 2011 Jan 13.
Bioorg Med Chem Lett. 2011.
PMID: 21295979
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