Niv-Spector L - Search Results

1

Development and characterization of high affinity leptins and leptin antagonists.

Shpilman M, Niv-Spector L, Katz M, Varol C, Solomon G, Ayalon-Soffer M, Boder E, Halpern Z, Elinav E, Gertler A. Shpilman M, et al. Among authors: niv spector l. J Biol Chem. 2011 Feb 11;286(6):4429-42. doi: 10.1074/jbc.M110.196402. Epub 2010 Nov 30. J Biol Chem. 2011. PMID: 21119198 Free PMC article.

2

Preparation of leptin antagonists by site-directed mutagenesis of human, ovine, rat, and mouse leptin's site III: implications on blocking undesired leptin action in vivo.

Solomon G, Niv-Spector L, Gonen-Berger D, Callebaut I, Djiane J, Gertler A. Solomon G, et al. Among authors: niv spector l. Ann N Y Acad Sci. 2006 Dec;1091:531-9. doi: 10.1196/annals.1378.094. Ann N Y Acad Sci. 2006. PMID: 17341642

3

The obese phenotype-inducing N82K mutation in human leptin disrupts receptor-binding and biological activity.

Niv-Spector L, Shpilman M, Grupi A, Gertler A. Niv-Spector L, et al. Mol Genet Metab. 2010 Jun;100(2):193-7. doi: 10.1016/j.ymgme.2010.02.015. Epub 2010 Feb 25. Mol Genet Metab. 2010. PMID: 20307995

4

Large-scale preparation and characterization of non-pegylated and pegylated superactive ovine leptin antagonist.

Niv-Spector L, Shpilman M, Boisclair Y, Gertler A. Niv-Spector L, et al. Protein Expr Purif. 2012 Feb;81(2):186-92. doi: 10.1016/j.pep.2011.10.003. Epub 2011 Oct 21. Protein Expr Purif. 2012. PMID: 22040607

5

Preparation and characterization of mouse IL-22 and its four single-amino-acid muteins that act as IL-22 receptor-1 antagonists.

Niv-Spector L, Shpilman M, Levi-Bober M, Katz M, Varol C, Elinav E, Gertler A. Niv-Spector L, et al. Protein Eng Des Sel. 2012 Aug;25(8):397-404. doi: 10.1093/protein/gzs030. Epub 2012 Jun 12. Protein Eng Des Sel. 2012. PMID: 22691704

6

Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists.

Niv-Spector L, Gonen-Berger D, Gourdou I, Biener E, Gussakovsky EE, Benomar Y, Ramanujan KV, Taouis M, Herman B, Callebaut I, Djiane J, Gertler A. Niv-Spector L, et al. Biochem J. 2005 Oct 15;391(Pt 2):221-30. doi: 10.1042/BJ20050457. Biochem J. 2005. PMID: 15952938 Free PMC article.

7

Large-scale preparation of biologically active mouse and rat leptins and their L39A/D40A/F41A muteins which act as potent antagonists.

Salomon G, Niv-Spector L, Gussakovsky EE, Gertler A. Salomon G, et al. Protein Expr Purif. 2006 May;47(1):128-36. doi: 10.1016/j.pep.2005.09.016. Epub 2005 Oct 21. Protein Expr Purif. 2006. PMID: 16289983

8

Pegylated leptin antagonist is a potent orexigenic agent: preparation and mechanism of activity.

Elinav E, Niv-Spector L, Katz M, Price TO, Ali M, Yacobovitz M, Solomon G, Reicher S, Lynch JL, Halpern Z, Banks WA, Gertler A. Elinav E, et al. Among authors: niv spector l. Endocrinology. 2009 Jul;150(7):3083-91. doi: 10.1210/en.2008-1706. Epub 2009 Apr 2. Endocrinology. 2009. PMID: 19342450 Free PMC article.

9

Mapping leptin-interacting sites in recombinant leptin-binding domain (LBD) subcloned from chicken leptin receptor.

Niv-Spector L, Raver N, Friedman-Einat M, Grosclaude J, Gussakovsky EE, Livnah O, Gertler A. Niv-Spector L, et al. Biochem J. 2005 Sep 1;390(Pt 2):475-84. doi: 10.1042/BJ20050233. Biochem J. 2005. PMID: 15842201 Free PMC article.

10

Principles of strategic drug delivery to the brain (SDDB): development of anorectic and orexigenic analogs of leptin.

Banks WA, Gertler A, Solomon G, Niv-Spector L, Shpilman M, Yi X, Batrakova E, Vinogradov S, Kabanov AV. Banks WA, et al. Among authors: niv spector l. Physiol Behav. 2011 Nov 30;105(1):145-9. doi: 10.1016/j.physbeh.2011.05.024. Epub 2011 Jun 6. Physiol Behav. 2011. PMID: 21669216 Free PMC article. Review.

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