Sixma TK - Search Results

1

Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin.

El Oualid F, Merkx R, Ekkebus R, Hameed DS, Smit JJ, de Jong A, Hilkmann H, Sixma TK, Ovaa H. El Oualid F, et al. Among authors: sixma tk. Angew Chem Int Ed Engl. 2010 Dec 27;49(52):10149-53. doi: 10.1002/anie.201005995. Angew Chem Int Ed Engl. 2010. PMID: 21117055 Free PMC article. No abstract available.

2

The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains.

Marteijn JA, van der Meer LT, Smit JJ, Noordermeer SM, Wissink W, Jansen P, Swarts HG, Hibbert RG, de Witte T, Sixma TK, Jansen JH, van der Reijden BA. Marteijn JA, et al. Among authors: sixma tk. Leukemia. 2009 Aug;23(8):1480-9. doi: 10.1038/leu.2009.57. Epub 2009 Apr 2. Leukemia. 2009. PMID: 19340006

3

Nonhydrolyzable ubiquitin-isopeptide isosteres as deubiquitinating enzyme probes.

Shanmugham A, Fish A, Luna-Vargas MP, Faesen AC, El Oualid F, Sixma TK, Ovaa H. Shanmugham A, et al. Among authors: sixma tk. J Am Chem Soc. 2010 Jul 7;132(26):8834-5. doi: 10.1021/ja101803s. J Am Chem Soc. 2010. PMID: 20540574

4

Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase.

Faesen AC, Dirac AM, Shanmugham A, Ovaa H, Perrakis A, Sixma TK. Faesen AC, et al. Among authors: sixma tk. Mol Cell. 2011 Oct 7;44(1):147-59. doi: 10.1016/j.molcel.2011.06.034. Mol Cell. 2011. PMID: 21981925 Free article.

5

The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types.

Faesen AC, Luna-Vargas MP, Geurink PP, Clerici M, Merkx R, van Dijk WJ, Hameed DS, El Oualid F, Ovaa H, Sixma TK. Faesen AC, et al. Among authors: sixma tk. Chem Biol. 2011 Dec 23;18(12):1550-61. doi: 10.1016/j.chembiol.2011.10.017. Chem Biol. 2011. PMID: 22195557

6

The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.

Smit JJ, Monteferrario D, Noordermeer SM, van Dijk WJ, van der Reijden BA, Sixma TK. Smit JJ, et al. Among authors: sixma tk. EMBO J. 2012 Oct 3;31(19):3833-44. doi: 10.1038/emboj.2012.217. Epub 2012 Aug 3. EMBO J. 2012. PMID: 22863777 Free PMC article.

7

Target specificity of the E3 ligase LUBAC for ubiquitin and NEMO relies on different minimal requirements.

Smit JJ, van Dijk WJ, El Atmioui D, Merkx R, Ovaa H, Sixma TK. Smit JJ, et al. Among authors: sixma tk. J Biol Chem. 2013 Nov 1;288(44):31728-37. doi: 10.1074/jbc.M113.495846. Epub 2013 Sep 12. J Biol Chem. 2013. PMID: 24030825 Free PMC article.

8

RBR E3-ligases at work.

Smit JJ, Sixma TK. Smit JJ, et al. Among authors: sixma tk. EMBO Rep. 2014 Feb;15(2):142-54. doi: 10.1002/embr.201338166. Epub 2014 Jan 27. EMBO Rep. 2014. PMID: 24469331 Free PMC article. Review.

9

Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.

Sahtoe DD, van Dijk WJ, El Oualid F, Ekkebus R, Ovaa H, Sixma TK. Sahtoe DD, et al. Among authors: sixma tk. Mol Cell. 2015 Mar 5;57(5):887-900. doi: 10.1016/j.molcel.2014.12.039. Epub 2015 Feb 19. Mol Cell. 2015. PMID: 25702870 Free PMC article.

10

BAP1/ASXL1 recruitment and activation for H2A deubiquitination.

Sahtoe DD, van Dijk WJ, Ekkebus R, Ovaa H, Sixma TK. Sahtoe DD, et al. Among authors: sixma tk. Nat Commun. 2016 Jan 7;7:10292. doi: 10.1038/ncomms10292. Nat Commun. 2016. PMID: 26739236 Free PMC article.

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