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Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling.
Kickstein E, Krauss S, Thornhill P, Rutschow D, Zeller R, Sharkey J, Williamson R, Fuchs M, Köhler A, Glossmann H, Schneider R, Sutherland C, Schweiger S. Kickstein E, et al. Among authors: sutherland c. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21830-5. doi: 10.1073/pnas.0912793107. Epub 2010 Nov 22. Proc Natl Acad Sci U S A. 2010. PMID: 21098287 Free PMC article.
Insulin resistance in the brain: an old-age or new-age problem?
Williamson R, McNeilly A, Sutherland C. Williamson R, et al. Among authors: sutherland c. Biochem Pharmacol. 2012 Sep 15;84(6):737-45. doi: 10.1016/j.bcp.2012.05.007. Epub 2012 May 16. Biochem Pharmacol. 2012. PMID: 22634336 Review.
Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression.
Cole AR, Noble W, van Aalten L, Plattner F, Meimaridou R, Hogan D, Taylor M, LaFrancois J, Gunn-Moore F, Verkhratsky A, Oddo S, LaFerla F, Giese KP, Dineley KT, Duff K, Richardson JC, Yan SD, Hanger DP, Allan SM, Sutherland C. Cole AR, et al. Among authors: sutherland c. J Neurochem. 2007 Nov;103(3):1132-44. doi: 10.1111/j.1471-4159.2007.04829.x. Epub 2007 Aug 7. J Neurochem. 2007. PMID: 17683481 Free article.
868 results