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Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling.
Kickstein E, Krauss S, Thornhill P, Rutschow D, Zeller R, Sharkey J, Williamson R, Fuchs M, Köhler A, Glossmann H, Schneider R, Sutherland C, Schweiger S. Kickstein E, et al. Among authors: schweiger s. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21830-5. doi: 10.1073/pnas.0912793107. Epub 2010 Nov 22. Proc Natl Acad Sci U S A. 2010. PMID: 21098287 Free PMC article.
Protein phosphatase 2A (PP2A)-specific ubiquitin ligase MID1 is a sequence-dependent regulator of translation efficiency controlling 3-phosphoinositide-dependent protein kinase-1 (PDPK-1).
Aranda-Orgillés B, Rutschow D, Zeller R, Karagiannidis AI, Köhler A, Chen C, Wilson T, Krause S, Roepcke S, Lilley D, Schneider R, Schweiger S. Aranda-Orgillés B, et al. Among authors: schweiger s. J Biol Chem. 2011 Nov 18;286(46):39945-57. doi: 10.1074/jbc.M111.224451. Epub 2011 Sep 19. J Biol Chem. 2011. PMID: 21930711 Free PMC article.
Control of mTORC1 signaling by the Opitz syndrome protein MID1.
Liu E, Knutzen CA, Krauss S, Schweiger S, Chiang GG. Liu E, et al. Among authors: schweiger s. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8680-5. doi: 10.1073/pnas.1100131108. Epub 2011 May 9. Proc Natl Acad Sci U S A. 2011. PMID: 21555591 Free PMC article.
The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu.
Schweiger S, Dorn S, Fuchs M, Köhler A, Matthes F, Müller EC, Wanker E, Schneider R, Krauß S. Schweiger S, et al. J Biol Chem. 2014 Nov 14;289(46):31805-31817. doi: 10.1074/jbc.M113.541219. Epub 2014 Oct 2. J Biol Chem. 2014. PMID: 25278022 Free PMC article.
124 results