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Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling.
Kickstein E, Krauss S, Thornhill P, Rutschow D, Zeller R, Sharkey J, Williamson R, Fuchs M, Köhler A, Glossmann H, Schneider R, Sutherland C, Schweiger S. Kickstein E, et al. Among authors: glossmann h. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21830-5. doi: 10.1073/pnas.0912793107. Epub 2010 Nov 22. Proc Natl Acad Sci U S A. 2010. PMID: 21098287 Free PMC article.
Metformin and Aging: A Review.
Glossmann HH, Lutz OMD. Glossmann HH, et al. Gerontology. 2019;65(6):581-590. doi: 10.1159/000502257. Epub 2019 Sep 13. Gerontology. 2019. PMID: 31522175 Review.
New insights into tetrahydrobiopterin pharmacodynamics from Pah enu1/2, a mouse model for compound heterozygous tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency.
Lagler FB, Gersting SW, Zsifkovits C, Steinbacher A, Eichinger A, Danecka MK, Staudigl M, Fingerhut R, Glossmann H, Muntau AC. Lagler FB, et al. Among authors: glossmann h. Biochem Pharmacol. 2010 Nov 15;80(10):1563-71. doi: 10.1016/j.bcp.2010.07.042. Epub 2010 Aug 10. Biochem Pharmacol. 2010. PMID: 20705059
Pharmacology of metformin - An update.
Glossmann HH, Lutz OMD. Glossmann HH, et al. Eur J Pharmacol. 2019 Dec 15;865:172782. doi: 10.1016/j.ejphar.2019.172782. Epub 2019 Nov 6. Eur J Pharmacol. 2019. PMID: 31705902 Review.
208 results